Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Panov, V; Minigalieva, I; Bushueva, T; Fröhlich, E; Meindl, C; Absenger-Novak, M; Shur, V; Shishkina, E; Gurvich, V; Privalova, L; Katsnelson, BA.
Some Peculiarities in the Dose Dependence of Separate and Combined In Vitro Cardiotoxicity Effects Induced by CdS and PbS Nanoparticles With Special Attention to Hormesis Manifestations.
Dose Response. 2020; 18(1):1559325820914180-1559325820914180
Doi: 10.1177/1559325820914180
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- Co-Autor*innen der Med Uni Graz
- Absenger-Novak Markus
- Fröhlich Eleonore
- Meindl Claudia
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- Abstract:
- Spherical nanoparticles (NPs) of cadmium and lead sulfides (diameter 37 ± 5 and 24 ± 4 nm, respectively) have been found to be cytotoxic for HL-1 cardiomyocytes as evidenced by decrease in adenosine triphosphate-dependent luminescence. Cadmium sulfide (CdS)-NPs were discovered to produce a much greater cytotoxic impact than lead sulphide (PbS)-NP. Given the same dose range, CdS-NP reduced the number of calcium spikes. A similar effect was observed for small doses of PbS-NP. In addition to cell hypertrophy under the impact of certain doses of CdS-NP and PbS-NP, doses causing cardiomyocyte size reduction were identified. For these 3 outcomes, we obtained both monotonic "dose-response" functions (well approximated by the hyperbolic function) and different variants of non-monotonic ones for which we found adequate mathematical expressions by modifying certain models of hormesis available in the literature. Data analysis using a response surface linear model with a cross-term provided new support to the previously established postulate that a diversity of types of joint action characteristic of one and the same pair of damaging agents is one of the important assertions of the general theory of combined toxicity. © The Author(s) 2020.
- Find related publications in this database (Keywords)
- nanoparticles
- cadmium
- lead
- impact on cardiomyocytes in vitro
- hormesis