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Eber, B; Schumacher, M; Zweiker, R; Pokan, R; Klein, W.
Nisoldipine in comparison with long-term nitrates
ACTA MED AUST. 1992; 19(5): 137-139.
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Co-authors Med Uni Graz: Schumacher Martin; Zweiker Robert
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Abstract:: Nisoldipine represents a new attractive second generation calcium channel blocker of the dihydropyridine-class for the treatment of all types of coronary artery disease. The effect on chronic ischemia is comparable to long-acting nitrates, side-effects have been rarely observed. The advantages will be the high vascular selectivity with only slight negative inotropic effect as well as a long-lasting positive influence on the myocardial metabolism. Up to now, no studies have been reported which compare nisoldipine and long-acting nitrates directly, but this calcium antagonist appears to influence duration and intensity of symptomatic and silent episodes of ischemia similar to the nitrates.
Find related publications in this database (using NLM MeSH Indexing): Angina Pectoris - drug therapy; Animals - drug therapy; Coronary Circulation - drug effects; Coronary Disease - drug therapy; Coronary Vasospasm - drug therapy; Humans - drug therapy; Myocardial Ischemia - drug therapy; Nisoldipine - therapeutic use; Nitrates - therapeutic use
Find related publications in this database (Keywords): Nisoldipine; Long-Acting Nitrates; Coronary Artery Disease; Endothelium-Derived Relaxing Factor; Silent Ischemia