Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stemler, J; Bruns, C; Mellinghoff, SC; Alakel, N; Akan, H; Ananda-Rajah, M; Auberger, J; Bojko, P; Chandrasekar, PH; Chayakulkeeree, M; Cozzi, JA; de Kort, EA; Groll, AH; Heath, CH; Henze, L; Hernandez Jimenez, M; Kanj, SS; Khanna, N; Koldehoff, M; Lee, DG; Mager, A; Marchesi, F; Martino-Bufarull, R; Nucci, M; Oksi, J; Pagano, L; Phillips, B; Prattes, J; Pyrpasopoulou, A; Rabitsch, W; Schalk, E; Schmidt-Hieber, M; Sidharthan, N; Soler-Palacín, P; Stern, A; Weinbergerová, B; El Zakhem, A; Cornely, OA; Koehler, P.
Baseline Chest Computed Tomography as Standard of Care in High-Risk Hematology Patients.
J Fungi (Basel). 2020; 6(1):
Doi: 10.3390/jof6010036
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- Abstract:
- Baseline chest computed tomography (BCT) in high-risk hematology patients allows for the early diagnosis of invasive pulmonary aspergillosis (IPA). The distribution of BCT implementation in hematology departments and impact on outcome is unknown. A web-based questionnaire was designed. International scientific bodies were invited. The estimated numbers of annually treated hematology patients, chest imaging timepoints and techniques, IPA rates, and follow-up imaging were assessed. In total, 142 physicians from 43 countries participated. The specialties included infectious diseases (n = 69; 49%), hematology (n = 68; 48%), and others (n = 41; 29%). BCT was performed in 57% (n = 54) of 92 hospitals. Upon the diagnosis of malignancy or admission, 48% and 24% performed BCT, respectively, and X-ray was performed in 48% and 69%, respectively. BCT was more often used in hematopoietic cell transplantation and in relapsed acute leukemia. European centers performed BCT in 59% and non-European centers in 53%. Median estimated IPA rate was 8% and did not differ between BCT (9%; IQR 5-15%) and non-BCT centers (7%; IQR 5-10%) (p = 0.69). Follow-up computed tomography (CT) for IPA was performed in 98% (n = 90) of centers. In high-risk hematology patients, baseline CT is becoming a standard-of-care. Chest X-ray, while inferior, is still widely used. Randomized, controlled trials are needed to investigate the impact of BCT on patient outcome.
- Find related publications in this database (Keywords)
- invasive aspergillosis
- antifungal prophylaxis
- infection in hematology