Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Perwein, T; Lackner, H; Ebetsberger-Dachs, G; Beham-Schmid, C; Zach, K; Tamesberger, M; Simonitsch-Klupp, I; Lüftinger, R; Dworzak, M; Mann, G; Benesch, M; Attarbaschi, A, , Austrian, Society, of, Pediatric, Hematology, and, Oncology, and, the, Austrian, Berlin-Frankfurt-Münster, (BFM), Study, Group.
Management of children and adolescents with gray zone lymphoma: A case series.
Pediatr Blood Cancer. 2020; 67(5):e28206
Doi: 10.1002/pbc.28206
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- Führende Autor*innen der Med Uni Graz
- Perwein Thomas
- Co-Autor*innen der Med Uni Graz
- Beham-Schmid Christine
- Benesch Martin
- Lackner Herwig
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- Abstract:
- BACKGROUND: Data on management of gray zone lymphoma (GZL) in children and adolescents are scarce. PROCEDURE: This retrospective study assessed clinical characteristics and outcome in six Austrian patients with GZL less than 18 years of age (male-to-female ratio: 1:1; median age: 15.8 years). RESULTS: Two patients each had a classical Hodgkin lymphoma (cHL)-like and composite GZL subtype, and one patient each had a large B-cell non-Hodgkin lymphoma (LBCL)-like and sequential GZL subtype. All had advanced disease with mediastinal and extranodal involvement. Five patients received an LBCL- and one patient a cHL-directed polychemotherapy ± radiotherapy. Out of the former patients, three survived, including two who relapsed and underwent high-dose chemotherapy with autologous stem cell rescue. The latter patient survived. CONCLUSIONS: GZL remains a diagnostic and therapeutic challenge, necessitating the development of novel treatment concepts performed in a prospective setting.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent - administration & dosage
- Austria - administration & dosage
- Autografts - administration & dosage
- Chemoradiotherapy - administration & dosage
- Female - administration & dosage
- Follow-Up Studies - administration & dosage
- Humans - administration & dosage
- Lymphoma, Large B-Cell, Diffuse - diagnosis, therapy
- Male - administration & dosage
- Mediastinal Neoplasms - diagnosis, therapy
- Retrospective Studies - administration & dosage
- Stem Cell Transplantation - administration & dosage
- Find related publications in this database (Keywords)
- checkpoint inhibitors
- gray zone lymphoma
- outcome
- relapse
- treatment