Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Desoye, G; Cervar-Zivkovic, M.
Diabetes Mellitus, Obesity, and the Placenta.
OBSTET GYNECOL CLIN N AMER. 2020; 47(1): 65-+.
Doi: 10.1016/j.ogc.2019.11.001
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Desoye Gernot
- Co-Autor*innen der Med Uni Graz
- Cervar-Zivkovic Mila
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- Abstract:
- The placenta is exposed to metabolic derangements in the maternal and fetal circulation. The effects of the early placental "exposome" determine further trajectories. Overstimulation of the fetal pancreas in early gestation results in fetal hyperinsulinemia, augmenting glucose transfer with adverse effects on the fetus. The manifold placental changes at the end of pregnancy can be regarded as adaptive responses to protect the fetus from diabetes and obesity. The causal role of the placenta, if any, in mediating long-term effects on offspring development is an important area of current and future research.
- Find related publications in this database (Keywords)
- Insulin
- Glucose
- Placental development
- Fetal phenotype
- Sexual dimorphism
- Stress