Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lackner, A; Heber, D; Bosch, P; Adelsmayr, G; Duftner, C; Ficjan, A; Gretler, J; Hermann, J; Husic, R; Graninger, WB; Dejaco, C.
Ultrasound verified enthesophytes are associated with radiographic progression at entheses in psoriatic arthritis.
Rheumatology (Oxford). 2020; 59(10):2893-2897
Doi: 10.1093/rheumatology/keaa028
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Dejaco Christian
- Lackner Angelika
- Co-Autor*innen der Med Uni Graz
- Adelsmayr Gabriel
- Bosch Philipp
- Ficjan Anja
- Graninger Winfried
- Gretler Judith
- Hermann Josef
- Husic Rusmir
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- Abstract:
- OBJECTIVES: The aim of this prospective study was to examine whether ultrasound or clinical abnormalities at enthesal sites predict radiographic progression at entheses in psoriatic arthritis (PsA). METHODS: Consecutive PsA patients were included and subjected to clinical and ultrasound assessments at 14 entheses at baseline, 6 and 12 months. Radiographs were performed at 0 and 12 months. By US, we investigated structural (erosions, osteophytes) and inflammatory changes [grey scale (0-32) and power Doppler (0-14, range global ultrasound score 0-140)], and radiographs were evaluated for enthesophytes and erosions (score range 0-56). Multivariate regression models were conducted to identify the possible association of clinical and ultrasound findings with radiographic progression. RESULTS: We examined 83 patients at baseline, of whom 43 (51.8%) had complete clinical, ultrasound and X-ray data. Twenty-four of 43 patients (55.8%) developed radiographic progression of entheses. These patients were younger (49.6 vs 59.3, P =0.005), had shorter disease duration (9.7 vs 17.9 years, P=0.015) and lower clinical disease activity at 6-months [disease activity in psoriatic arthritis (DAPSA) 6.7 vs 17.0, P=0.018] as compared with patients without progression. Non-progressors had higher ultrasound enthesophyte scores at baseline than progressors (20 vs 15, P<0.05). The multivariate regression analysis revealed that 48.6% of the variance of the X-ray score at 12-months follow-up (RegcoeffB = 0.827, P=0.000) could be explained by the baseline US enthesophyte score. CONCLUSION: Our data indicate that radiographic progression at entheses is linked with age, disease duration and ultrasound verified enthesophytes at baseline. No other ultrasound parameter predicted radiographic progression at entheses.
- Find related publications in this database (using NLM MeSH Indexing)
- Age Factors - administration & dosage
- Arthritis, Psoriatic - diagnostic imaging
- Disease Progression - administration & dosage
- Enthesopathy - diagnostic imaging
- Humans - administration & dosage
- Middle Aged - administration & dosage
- Prospective Studies - administration & dosage
- Radiography - administration & dosage
- Regression Analysis - administration & dosage
- Ultrasonography - administration & dosage
- Find related publications in this database (Keywords)
- psoriatic arthritis
- entheses
- radiographic progression
- enthesophytes
- ultrasound