Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Hofmann, P; Melisch, B; Zapotoczky, HG; Kulhanek, F.
Neuroleptic low-dose long-term strategy and intermittent therapy strategy in chronic schizophrenia--a critical review
FORTSCHR NEUROL PSYCHIAT. 1993; 61(6): 195-200.
Doi: 10.1055/s-2007-999087
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Hofmann Peter
- Co-Autor*innen der Med Uni Graz
- Melisch Barbara
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- Abstract:
- Much effort has been devoted during the past decade in finding new therapeutic approaches to cope with the commonly occurring adverse side effects of long-term neuroleptic maintenance treatment of schizophrenics, such as, in particular, akathisia, parkinsonian symptoms and tardive dyskinesia. Both low-dose maintenance (e.g. long-term treatment at dosages reduced to one-fifth or even less of conventional dosage levels in remitted and stable schizophrenics) and intermittent or-target medication strategies (e.g. discontinuation of neuroleptics in remitted stable chronic schizophrenics, aimed at resuming the medication as soon as prodromal signs of a relapse or actual relapses occur) might eventually imply for many schizophrenics a substantial reduction in total long-term neuroleptic dosages. This may lead to a reduction in the incidence of side effects and to an improvement in social integration. A critical review of the results published so far arrives at the following conclusions: 1. low-dose maintenance therapy is just as effective as a standard dose regimen and even superior to intermittent (target) medication. Especially if the dosage is increased in case of exacerbations; 2. these results are representative for a very small group of patients only, since the study populations were highly selective.
- Find related publications in this database (using NLM MeSH Indexing)
- Antipsychotic Agents - administration and dosage
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