Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mutgan, AC; Besikcioglu, HE; Wang, S; Friess, H; Ceyhan, GO; Demir, IE.
Insulin/IGF-driven cancer cell-stroma crosstalk as a novel therapeutic target in pancreatic cancer.
Mol Cancer. 2018; 17(1):66-66
Doi: 10.1186/s12943-018-0806-0
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- Führende Autor*innen der Med Uni Graz
- Mutgan Redolfi Ayse Ceren
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- Abstract:
- Pancreatic ductal adenocarcinoma (PDAC) is unrivalled the deadliest gastrointestinal cancer in the western world. There is substantial evidence implying that insulin and insulin-like growth factor (IGF) signaling axis prompt PDAC into an advanced stage by enhancing tumor growth, metastasis and by driving therapy resistance. Numerous efforts have been made to block Insulin/IGF signaling pathway in cancer therapy. However, therapies that target the IGF1 receptor (IGF-1R) and IGF subtypes (IGF-1 and IGF-2) have been repeatedly unsuccessful. This failure may not only be due to the complexity and homology that is shared by Insulin and IGF receptors, but also due to the complex stroma-cancer interactions in the pancreas. Shedding light on the interactions between the endocrine/exocrine pancreas and the stroma in PDAC is likely to steer us toward the development of novel treatments. In this review, we highlight the stroma-derived IGF signaling and IGF-binding proteins as potential novel therapeutic targets in PDAC.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antineoplastic Agents - pharmacology
- Cancer-Associated Fibroblasts - metabolism
- Cancer-Associated Fibroblasts - pathology
- Cell Communication - drug effects
- Humans -
- Insulin - metabolism
- Pancreatic Neoplasms - drug therapy
- Pancreatic Neoplasms - metabolism
- Pancreatic Neoplasms - pathology
- Signal Transduction - drug effects
- Somatomedins - metabolism
- Stromal Cells - metabolism
- Stromal Cells - pathology
- Find related publications in this database (Keywords)
- IGF-1
- Insulin
- Pancreatic cancer
- Stroma