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SHR Neuro Cancer Cardio Lipid Metab Microb
Seifert, T; Bauer, J; Weissert, R; Fazekas, F; Storch, MK.
Differential expression of sonic hedgehog immunoreactivity during lesion evolution in autoimmune encephalomyelitis.
J NEUROPATHOL EXP NEUROL. 2005; 64(5): 404-411.
Doi: 10.1093/jnen/64.5.404
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- Leading authors Med Uni Graz
- Seifert-Held Thomas
- Storch Maria
- Co-authors Med Uni Graz
- Fazekas Franz
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- Abstract:
- The signaling molecule Sonic hedgehog (Shh) is involved in several processes of central nervous system development. Recent reports indicate that Shh expression plays a role also in certain pathologic conditions in the adult brain, including multiple sclerosis and its animal model. However, the role of Shh signaling in immune-mediated demyelinating disease remains still uncertain. The aim of our study was to investigate the distribution pattern of Shh immunoreactivity (Shh-IR) during lesion evolution in myelin-oligodendrocyte-glycoprotein-induced experimental autoimmune encephalomyelitis (MOG-EAE), a model strongly mimicking multiple sclerosis. MOG-EAE was actively induced in DA rats. Histologic evaluation was performed with light and confocal microscopy on paraffin-embedded central nervous system sections from days 20 to 120 after active immunization. Shh-IR was present within the lesions of MOG-EAE during all stages of lesion evolution. The highest staining intensity for Shh was found in remyelinating lesions. In actively demyelinating, inactive demyelinated lesions, and in remyelinating lesions, Shh-IR was detected in macrophages, endothelium, and astrocytes. Shh-IR in axons was exclusively present in remyelinating lesions. Although the exact molecular mechanisms of the Shh-signaling pathway in experimental autoimmune encephalomyelitis are yet to be determined, our findings may imply a role of Shh signaling in facilitating remyelination.
- Find related publications in this database (using NLM MeSH Indexing)
- 2',3'-Cyclic-Nucleotide Phosphodiesterases - metabolism
- Animals - metabolism
- Animals, Newborn - metabolism
- Brain - metabolism
- Cell Count - methods
- Demyelinating Diseases - metabolism
- Disease Models, Animal - metabolism
- Female - metabolism
- Gene Expression Regulation, Developmental - physiology
- Glial Fibrillary Acidic Protein - metabolism
- Hedgehog Proteins - metabolism
- Microscopy, Confocal - methods
- Myelin Proteolipid Protein - metabolism
- Myelin Sheath - metabolism
- Myelin-Associated Glycoprotein - metabolism
- Neuritis, Autoimmune, Experimental - chemically induced
- Neurofilament Proteins - metabolism
- Neuroglia - metabolism
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- Time Factors - metabolism
- Trans-Activators - metabolism
- Find related publications in this database (Keywords)
- experimental autoimmune encephalomyelitis
- multiple sclerosis
- myelin oligodendrocyte glycoprotein
- remyelination
- sonic hedgehog