Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Kessler, HH.
Comparison of currently available assays for detection of hepatitis B virus DNA in the routine diagnostic laboratory.
EXPERT REV MOL DIAGN. 2005; 5(4): 531-536.
Doi: 10.1586/14737159.5.4.531
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Kessler Harald
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- Abstract:
- Infection with the hepatitis B virus (HBV) continues to present diagnostic and therapeutic challenges worldwide. Today, many routine diagnostic laboratories have implemented assays based on molecular techniques for the detection of HBV DNA. However, the standard algorithm for specific diagnosis of HBV infection still relies on serologic testing. Molecular assays are employed for pretreatment evaluation, clinical staging and monitoring of antiviral therapy. Furthermore, molecular methods are essential for identification of mutations in the HBV genome. Although a continuous improvement of assay performance has been observed during recent years, lack of comparability of different molecular assays remains a problem to be resolved in the future. The limited range of linearity when employing conventional PCR will be overcome by using real-time assays.
- Find related publications in this database (using NLM MeSH Indexing)
- DNA, Viral - analysis
- Hepatitis B - diagnosis
- Hepatitis B Antibodies - immunology
- Hepatitis B virus - genetics
- Humans - genetics
- Immunotherapy - genetics
- Find related publications in this database (Keywords)
- hepatitis B virus
- molecular testing
- routine diagnostic laboratory