Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Loew, M; Hoffmann, MM; Hahmann, H; März, W; Rothenbacher, D; Brenner, H.
Smoking, apolipoprotein E genotype, and early onset of coronary heart disease.
Eur J Cardiovasc Prev Rehabil. 2005; 12(3):268-270
Doi: 10.1097/00149831-200506000-00013
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- Co-authors Med Uni Graz
- März Winfried
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- Abstract:
- BACKGROUND: We examined the association between smoking, apolipoprotein E (ApoE) genotype, and early onset of coronary heart disease (CHD). DESIGN AND METHODS: Smoking behaviour and ApoE genotype of 904 patients with CHD aged 30-70 years were assessed with respect to age at onset of CHD. RESULTS: The adjusted odds ratio for early onset of CHD (< or =55 years) was 1.86 (95% confidence interval, 1.31-2.62) for smokers compared to non-smokers. The ApoE genotype had no significant influence and there was no significant interaction between ApoE genotype and smoking. CONCLUSION: We found smoking but not ApoE genotype to be an independent risk factor for early onset of CHD.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Age of Onset -
- Aged -
- Apolipoproteins E - genetics
- Cohort Studies - genetics
- Coronary Disease - etiology
- Female - etiology
- Genotype - etiology
- Humans - etiology
- Male - etiology
- Middle Aged - etiology
- Risk Factors - etiology
- Smoking - adverse effects
- Find related publications in this database (Keywords)
- cardiovascular disease
- myocardial infarction
- genetics
- ApoE polymorphism
- smoking
- interaction