Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hiam, D; Smith, C; Voisin, S; Denham, J; Yan, X; Landen, S; Jacques, M; Alvarez-Romero, J; Garnham, A; Woessner, MN; Herrmann, M; Duque, G; Levinger, I; Eynon, N.
Aerobic capacity and telomere length in human skeletal muscle and leukocytes across the lifespan.
Aging (Albany NY). 2020; 12(1):359-369
Doi: 10.18632/aging.102627
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- Co-Autor*innen der Med Uni Graz
- Herrmann Markus
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- Abstract:
- A reduction in aerobic capacity and the shortening of telomeres are hallmarks of the ageing process. We examined whether a lower aerobic capacity is associated with shorter TL in skeletal muscle and/or leukocytes, across a wide age range of individuals. We also tested whether TL in human skeletal muscle (MTL) correlates with TL in leukocytes (LTL). Eighty-two recreationally active, healthy men from the Gene SMART cohort (31.4±8.2 years; body mass index (BMI)=25.3±3.3kg/m2), and 11 community dwelling older men (74.2±7.5years-old; BMI=28.7±2.8kg/m2) participated in the study. Leukocytes and skeletal muscle samples were collected at rest. Relative telomere length (T/S ratio) was measured by RT-PCR. Associations between TL, aerobic capacity (VO2 peak and peak power) and age were assessed with robust linear models. Older age was associated with shorter LTL (45% variance explained, P<0.001), but not MTL (P= 0.7). Aerobic capacity was not associated with MTL (P=0.5), nor LTL (P=0.3). MTL and LTL were correlated across the lifespan (rs=0.26, P=0.03). In healthy individuals, age explain most of the variability of LTL and this appears to be independent of individual aerobic capacity. Individuals with longer LTL also have a longer MTL, suggesting that there might be a shared molecular mechanism regulating telomere length.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aerobiosis - genetics
- Aging - genetics
- Female -
- Humans -
- Leukocytes - metabolism
- Longevity - genetics
- Male -
- Muscle, Skeletal - metabolism
- Physical Fitness -
- Telomere - genetics
- Telomere - metabolism
- Telomere Homeostasis -
- Find related publications in this database (Keywords)
- exercise
- telomere
- ageing
- aerobic capacity