Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zakharova, IO; Sokolova, TV; Akhmetshina, AO; Avrova, NF.
Role of Protein Kinase Akt Activation in Protective Effect of Ganglioside GM1 on PC12 Cells Exposed to H2O2.
Bull Exp Biol Med. 2015; 159(5): 610-613.
Doi: 10.1007/s10517-015-3026-2
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Akhmetshina Alena
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- Abstract:
- Micro- and nanomolar concentrations of ganglioside GM1 improved viability of neuronal PC12 cells under conditions of oxidative stress and reduced H2O2-induced ROS accumulation in these cells. These effects were more pronounced at micromolar concentrations. GM1 in concentrations of 100 nM and 10 μM significantly and substantially increased basal activity of protein kinase B (Akt) (the level of phosphorylated Akt form), but had virtually no effect on its expression in PC12 cells. In the presence of PI3K inhibitor LY294002 preventing protein kinase Akt activation, the protective effect of GM1 significantly decreased. These findings suggest that activation of protein kinase Akt by GM1 contributes to improvement of PC12 cell viability by this ganglioside.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Antioxidants - pharmacology
- Chromones - pharmacology
- Dose-Response Relationship, Drug -
- Enzyme Activation - drug effects
- G(M1) Ganglioside - pharmacology
- Gene Expression Regulation - drug effects
- Hydrogen Peroxide - antagonists & inhibitors
- Hydrogen Peroxide - pharmacology
- L-Lactate Dehydrogenase - metabolism
- Morpholines - pharmacology
- Neuroprotective Agents - pharmacology
- Oxidative Stress -
- PC12 Cells -
- Phosphatidylinositol 3-Kinases - genetics
- Phosphatidylinositol 3-Kinases - metabolism
- Phosphoinositide-3 Kinase Inhibitors -
- Phosphorylation - drug effects
- Proto-Oncogene Proteins c-akt - agonists
- Proto-Oncogene Proteins c-akt - genetics
- Proto-Oncogene Proteins c-akt - metabolism
- Rats -
- Reactive Oxygen Species - antagonists & inhibitors
- Reactive Oxygen Species - metabolism
- Find related publications in this database (Keywords)
- ganglioside GM1
- protein kinase B (Akt)
- PC12 cells
- protective effect
- formation of reactive oxygen species