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SHR Neuro Cancer Cardio Lipid Metab Microb

Schrenk, P; Konstantiniuk, P; Wölfl, S; Bogner, S; Haid, A; Nemes, C; Jagoutz-Herzlinger, M; Redtenbacher, S.
Prediction of non-sentinel lymph node status in breast cancer with a micrometastatic sentinel node.
BRIT J SURG. 2005; 92: 707-713. Doi: 10.1002/bjs.4937
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Konstantiniuk Peter
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Abstract:: Background: Axillary lymph node dissection (ALND) may not be necessary in women with breast cancer who have micrometastasis in a sentinel node (SN), owing to the low risk of non-SN (NSN) involvement. The aim of this study was to identify a subgroup of women with a micrometastatic SN and a negligible risk of positive NSNs in whom ALND may be avoided. Methods: Some 237 of 241 women with a macrometastatic SN and 122 of 138 with a micrometastatic SN underwent completion ALND and were compared with respect to NSN involvement. The 122 patients with SN micrometastasis were further analysed to determine factors that could predict the risk of positive NSNs. Results: A total of 121 (51.1 percent) of 237 women with SN macrometastasis had positive NSNs compared with 22 (18.0 per cent) of 122 with SN micrometastasis (P < 0.001). Multivariate analysis showed that size of SN micrometastasis (odds ratio 3.49 (95 per cent confidence interval (c.i.) 1.32 to 9.23); P = 0.012) and presence of lymphovascular invasion (odds ratio 0.23 (95 per cent c.i. 0.05 to 1.00); P = 0.050) were significantly associated with positive NSNs. SN micrometastasis less than 0.5 mm in diameter combined with absence of lymphovascular invasion was associated with an 8.5 per cent risk of NSN involvement. Conclusion: Size of micrometastasis and presence of lymphovascular invasion were significantly related to the risk of finding additional positive axillary lymph nodes when the SN contained only micrometastasis.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Aged, 80 and over -; Axilla -; Breast Neoplasms - pathology; Female - pathology; Follow-Up Studies - pathology; Humans - pathology; Immunohistochemistry - pathology; Lymph Node Excision - methods; Lymphatic Metastasis - pathology; Male - pathology; Middle Aged - pathology; Predictive Value of Tests - pathology; Prospective Studies - pathology; Regression Analysis - pathology; Risk Factors - pathology; Sentinel Lymph Node Biopsy - methods