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SHR Neuro Cancer Cardio Lipid Metab Microb

Nemeth, ZK; Mardare, NG; Czira, ME; Deak, G; Kiss, I; Mathe, Z; Remport, A; Ujszaszi, A; Covic, A; Molnar, MZ; Mucsi, I.
Serum osteoprotegerin is associated with pulse pressure in kidney transplant recipients.
Sci Rep. 2015; 5(1):14518-14518 Doi: 10.1038/srep14518 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Mathe Zoltan
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Abstract:: Pulse pressure (PP) reflects increased large artery stiffness, which is caused, in part, by arterial calcification in patients with chronic kidney disease. PP has been shown to predict both cardiovascular and cerebrovascular events in various patient populations, including kidney transplant (KTX) recipients. Osteoprotegerin (OPG) is a marker and regulator of arterial calcification, and it is related to cardiovascular survival in hemodialysis patients. Here we tested the hypothesis that OPG is associated with increased pulse pressure. We cross-sectionally analyzed the association between serum OPG and PP in a prevalent cohort of 969 KTX patients (mean age: 51 +/- --13 years, 57% male, 21% diabetics, mean eGFR 51 +/- 20 ml/min/1.73 m2). Independent associations were tested in a linear regression model adjusted for multiple covariables. PP was positively correlated with serum OPG (rho = 0.284, p < 0.001). Additionally, a positive correlation was seen between PP versus age (r = 0.358, p < 0.001), the Charlson Comorbidity Index (r = 0.232, p < 0.001), serum glucose (r = 0.172, p < 0.001), BMI (r = 0.133, p = 0.001) and serum cholesterol (r = 0.094, p = 0.003). PP was negatively correlated with serum Ca, albumin and eGFR. The association between PP and OPG remained significant after adjusting for multiple potentially relevant covariables (beta = 0.143, p < 0.001). We conclude that serum OPG is independently associated with pulse pressure in kidney transplant recipients.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Biomarkers - blood; Blood Pressure -; Comorbidity -; Cross-Sectional Studies -; Female -; Humans -; Immunosuppression -; Kidney Transplantation -; Male -; Middle Aged -; Osteoprotegerin - blood; Risk Factors -; Transplant Recipients -