Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Molnar, MZ; Eason, JD; Gaipov, A; Talwar, M; Potukuchi, PK; Joglekar, K; Remport, A; Mathe, Z; Mucsi, I; Novak, M; Kalantar-Zadeh, K; Kovesdy, CP.
History of psychosis and mania, and outcomes after kidney transplantation - a retrospective study.
Transpl Int. 2018; 31(5):554-565
Doi: 10.1111/tri.13127
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- Co-authors Med Uni Graz
- Mathe Zoltan
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- Abstract:
- History of psychosis or mania, if uncontrolled, both represent relative contraindications for kidney transplantation. We examined 3680 US veterans who underwent kidney transplantation. The diagnosis of history of psychosis/mania was based on a validated algorithm. Measured confounders were used to create a propensity score-matched cohort (n = 442). Associations between pretransplantation psychosis/mania and death with functioning graft, all-cause death, graft loss, and rejection were examined in survival models and logistic regression models. Post-transplant medication nonadherence was assessed using proportion of days covered (PDC) for tacrolimus and mycophenolic acid in both groups. The mean ± SD age of the cohort at baseline was 61 ± 11 years, 92% were male, and 66% and 27% of patients were white and African-American, respectively. Compared to patients without history of psychosis/mania, patients with a history of psychosis/mania had similar risk of death with functioning graft [subhazard ratio (SHR) (95% confidence interval (CI)): 0.94(0.42-2.09)], all-cause death [hazard ratio (95% CI): 1.04 (0.51-2.14)], graft loss [SHR (95% CI): 1.07 (0.45-2.57)], and rejection [odds ratio(95% CI): 1.23(0.60-2.53)]. Moreover, there was no difference in immunosuppressive drug PDC in patients with and without history of psychosis/mania (PDC: 76 ± 21% vs. 78 ± 19%, P = 0.529 for tacrolimus; PDC: 78 ± 17% vs. 79 ± 18%, P = 0.666 for mycophenolic acid). After careful selection, pretransplantation psychosis/mania is not associated with adverse outcomes in kidney transplant recipients. © 2018 Steunstichting ESOT.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Bipolar Disorder - complications
- Bipolar Disorder - drug therapy
- Cause of Death -
- Female -
- Graft Rejection - etiology
- Humans -
- Kidney Transplantation - mortality
- Male -
- Medication Adherence -
- Middle Aged -
- Psychotic Disorders - complications
- Psychotic Disorders - drug therapy
- Retrospective Studies -
- Find related publications in this database (Keywords)
- bipolar disorder
- kidney transplantation
- mortality
- schizophrenia
- survival