Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Hoyer, DP; Paul, A; Saner, F; Gallinat, A; Mathé, Z; Treckmann, JW; Schulze, M; Kaiser, GM; Canbay, A; Molmenti, E; Sotiropoulos, GC.
Safely expanding the donor pool: brain dead donors with history of temporary cardiac arrest.
Liver Int. 2015; 35(6):1756-1763
Doi: 10.1111/liv.12766
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Mathe Zoltan
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Cardiac arrest (CA) in deceased organ donors can potentially be associated with ischaemic organ injury, resulting in allograft dysfunction after liver transplantation (LT). The aim of this study was to analyse the influence of cardiac arrest in liver donors. We evaluated 884 consecutive adult patients undergoing LT at our Institution from September 2003 to December 2011. Uni- and multivariable analyses was performed to identify predictive factors of outcome and survival for organs from donors with (CA donor) and without (no CA donor) a history of cardiac arrest. We identified 77 (8.7%) CA donors. Median resuscitation time was 16.5 (1-150) minutes. Allografts from CA donors had prolonged CIT (p = 0.016), were obtained from younger individuals (p < 0.001), and had higher terminal preprocurement AST and ALT (p < 0.001) than those of no CA donors. 3-month, 1-year and 5-year survival for recipients of CA donor grafts was 79%, 76% and 57% and 72.1%, 65.1% and 53% for no CA donor grafts (log rank p = 0.435). Peak AST after LT was significantly lower in CA donor organs than in no CA donor ones (886U/l vs 1321U/l; p = 0.031). Multivariable analysis identified CIT as a risk factor for both patient and graft survival in CA donors. This analysis represents the largest cohort of liver donors with a history of cardiac arrest. Reasonable selection of these donors constitutes a safe approach to the expansion of the donor pool. Rapid allocation and implantation with diminution of CIT may further improve the outcomes of livers from CA donors. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Aged, 80 and over -
- Brain Death -
- Child -
- Child, Preschool -
- Cold Ischemia -
- Donor Selection -
- Female -
- Graft Survival -
- Heart Arrest - physiopathology
- Humans -
- Kaplan-Meier Estimate -
- Liver Transplantation - methods
- Male -
- Middle Aged -
- Multivariate Analysis -
- Retrospective Studies -
- Risk Factors -
- Tissue Donors - classification
- Tissue and Organ Harvesting - methods
- Transplant Recipients -
- Treatment Outcome -
- Warm Ischemia -
- Young Adult -
- Find related publications in this database (Keywords)
- donor pool
- donor resuscitation
- extended donor criteria
- risk assessment