Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fouzas, I; Paul, A; Becker, C; Vernadakis, S; Treckmann, JW; Máthé, Z; Gerken, G; Sotiropoulos, GC.
Orthotopic liver transplantation in patients with portal vein thrombosis in the absence of hepatocellular carcinoma.
Transplant Proc. 2012; 44(9):2734-2736
Doi: 10.1016/j.transproceed.2012.09.024
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Mathe Zoltan
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- Abstract:
- Liver transplantation (OLT) in the setting of portal vein thrombosis (PVT) has been a matter of controversy in the past. We herein report our experience with OLT for PVT in the absence of hepatocellular carcinoma. Data from patients undergoing OLT for end-stage liver disease, having a documented PVT before OLT, were reviewed. Twenty-five patients were included for the period July, 2003 to December, 2009. There were 20 men and 5 women of median age 57 years. Median values for waiting time and Model for End-Stage Liver Disease score were 150 days and 18, respectively. PVT was classified as grade II (n = 6), IIIa (n = 7), IIIb (n = 9), or IVa (n = 3). Partial portal vein resection/reconstruction, operative thrombectomy, and eversion thromboendovenectomy were performed in 2, 16, and 7 instances, respectively. After a median follow-up of 18 months, 14 patients are alive. Survival rates at 3, 6, 9, and 12, months and 3 years post-OLT were 68%, 64%, 61%, 61%, and 61%, respectively. PVT grade was a negative predictor of survival by Cox proportional hazard analysis (P = .0253). Despite the technical innovations in recent years, PVT grade correlated with poor patient survival irrespective of the surgical technique. Copyright © 2012 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Female -
- Humans -
- Kaplan-Meier Estimate -
- Liver Diseases - diagnosis
- Liver Diseases - etiology
- Liver Diseases - mortality
- Liver Diseases - surgery
- Liver Transplantation - adverse effects
- Liver Transplantation - mortality
- Male -
- Middle Aged -
- Portal Vein - surgery
- Proportional Hazards Models -
- Risk Factors -
- Severity of Illness Index -
- Thrombectomy - adverse effects
- Thrombectomy - mortality
- Time Factors -
- Treatment Outcome -
- Venous Thrombosis - complications
- Venous Thrombosis - diagnosis
- Venous Thrombosis - mortality
- Venous Thrombosis - surgery
- Waiting Lists -
- Young Adult -