Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Sukseree, S; Schwarze, UY; Gruber, R; Gruber, F; Quiles, Del, Rey, M; Mancias, JD; Bartlett, JD; Tschachler, E; Eckhart, L.
ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging.
Autophagy. 2020; 16(10):1851-1857
Doi: 10.1080/15548627.2019.1709764
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- Co-Autor*innen der Med Uni Graz
- Schwarze Uwe Yacine
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- Abstract:
- The incisors of rodents comprise an iron-rich enamel and grow throughout adult life, making them unique models of iron metabolism and tissue homeostasis during aging. Here, we deleted Atg7 (autophagy related 7) in murine ameloblasts, i.e. the epithelial cells that produce enamel. The absence of ATG7 blocked the transport of iron from ameloblasts into the maturing enamel, leading to a white instead of yellow surface of maxillary incisors. In aging mice, lack of ATG7 was associated with the growth of ectopic incisors inside severely deformed primordial incisors. These results suggest that 2 characteristic features of rodent incisors, i.e. deposition of iron on the enamel surface and stable growth during aging, depend on autophagic activity in ameloblasts. Abbreviations: ATG5: autophagy related 5; ATG7: autophagy related 7; CMV: cytomegalovirus; Cre: Cre recombinase; CT: computed tomography; FTH1: ferritin heavy polypeptide 1; GFP: green fluorescent protein; KRT5: keratin 5; KRT14: keratin 14; LGALS3: lectin, galactose binding, soluble 3; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; NCOA4: nuclear receptor coactivator 4; NRF2: nuclear factor, erythroid 2 like 2; SQSTM1: sequestosome 1.
- Find related publications in this database (using NLM MeSH Indexing)
- Aging - administration & dosage
- Ameloblasts - metabolism
- Animals - administration & dosage
- Autophagy - administration & dosage
- Autophagy-Related Protein 7 - metabolism, physiology
- Epithelial Cells - metabolism
- Epithelium - metabolism
- Female - administration & dosage
- Ferritins - metabolism
- Gene Deletion - administration & dosage
- Green Fluorescent Proteins - metabolism
- Homeostasis - administration & dosage
- Incisor - metabolism
- Iron - metabolism
- Male - administration & dosage
- Mice - administration & dosage
- Mice, Transgenic - administration & dosage
- Sequestosome-1 Protein - metabolism
- X-Ray Microtomography - administration & dosage
- Find related publications in this database (Keywords)
- Aging
- ameloblast
- ATG7
- autophagy
- epithelium
- ferritin
- hyperplasia
- iron
- secretion
- tooth