Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Amrein, K; Scherkl, M; Hoffmann, M; Neuwersch-Sommeregger, S; Köstenberger, M; Tmava, Berisha, A; Martucci, G; Pilz, S; Malle, O.
Vitamin D deficiency 2.0: an update on the current status worldwide.
Eur J Clin Nutr. 2020; 74(11):1498-1513
Doi: 10.1038/s41430-020-0558-y
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- Führende Autor*innen der Med Uni Graz
- Amrein Karin
- Co-Autor*innen der Med Uni Graz
- Hoffmann Magdalena
- Köstenberger Markus
- Malle Oliver
- Neuwersch-Sommeregger Stefan Matthias
- Pilz Stefan
- Tmava-Berisha Adelina
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- Abstract:
- Vitamin D testing and the use of vitamin D supplements have increased substantially in recent years. Currently, the role of vitamin D supplementation, and the optimal vitamin D dose and status, is a subject of debate, because large interventional studies have been unable to show a clear benefit (in mostly vitamin D replete populations). This may be attributed to limitations in trial design, as most studies did not meet the basic requirements of a nutrient intervention study, including vitamin D-replete populations, too small sample sizes, and inconsistent intervention methods regarding dose and metabolites. Vitamin D deficiency (serum 25-hydroxyvitamin D [25(OH)D] < 50 nmol/L or 20 ng/ml) is associated with unfavorable skeletal outcomes, including fractures and bone loss. A 25(OH)D level of >50 nmol/L or 20 ng/ml is, therefore, the primary treatment goal, although some data suggest a benefit for a higher threshold. Severe vitamin D deficiency with a 25(OH)D concentration below <30 nmol/L (or 12 ng/ml) dramatically increases the risk of excess mortality, infections, and many other diseases, and should be avoided whenever possible. The data on a benefit for mortality and prevention of infections, at least in severely deficient individuals, appear convincing. Vitamin D is clearly not a panacea, and is most likely efficient only in deficiency. Given its rare side effects and its relatively wide safety margin, it may be an important, inexpensive, and safe adjuvant therapy for many diseases, but future large and well-designed studies should evaluate this further. A worldwide public health intervention that includes vitamin D supplementation in certain risk groups, and systematic vitamin D food fortification to avoid severe vitamin D deficiency, would appear to be important. In this narrative review, the current international literature on vitamin D deficiency, its relevance, and therapeutic options is discussed.
- Find related publications in this database (using NLM MeSH Indexing)
- Dietary Supplements - administration & dosage
- Fractures, Bone - administration & dosage
- Humans - administration & dosage
- Vitamin D - administration & dosage
- Vitamin D Deficiency - drug therapy, epidemiology
- Vitamins - administration & dosage