Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Woltsche, N; Kruger, MA; Weger, M; Wolf, IH; Seidel, G.
Intravitreal Steroid Treatment for Uveitis Associated with Dabrafenib and Trametinib for Metastatic Cutaneous Melanoma.
Ocul Immunol Inflamm. 2021; 29(5):845-847
Doi: 10.1080/09273948.2019.1695860
(- Case Report)
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Seidel Gerald
- Woltsche Nora
- Co-authors Med Uni Graz
- Kruger Michael
- Weger Martin
- Wolf Ingrid
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- Abstract:
- Purpose: To report a case of bilateral retinal inflammation under long-term therapy with dabrafenib/trametinib for metastatic cutaneous melanoma.Methods: Retrospective chart review.Results: A 59-year-old patient with metastatic cutaneous melanoma diagnosed in 2004 under treatment with dabrafenib/trametinib since 2014 presented to our department with intraretinal hemorrhage and extrafoveal macula edema on the right eye and optic disc swelling on the left eye. The patient did not report visual complaints. After cessation of dabrafenib/trametinib and subconjunctival and intravitreal corticosteroid injections, optic disc swelling on the left eye recovered after 6 months. The macula edema on the right eye was treated with one intravitreal anti-VEGF (vascular endothelial growth factor) injection after encroaching upon the fovea 10 months after initial presentation. The final visual acuity was 20/20 on both eyes.Conclusion: Even after years of treatment with low dose dabrafenib/trametinib, ocular toxicity can develop. Such cases can respond well to intravitreal corticosteroids.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Combined Chemotherapy Protocols - adverse effects
- Coloring Agents - administration & dosage
- Fluorescein Angiography - administration & dosage
- Glucocorticoids - therapeutic use
- Humans - administration & dosage
- Imidazoles - administration & dosage
- Indocyanine Green - administration & dosage
- Intravitreal Injections - administration & dosage
- Macular Edema - chemically induced, drug therapy, physiopathology
- Melanoma - drug therapy
- Oximes - administration & dosage
- Papilledema - chemically induced, drug therapy, physiopathology
- Pyridones - administration & dosage
- Pyrimidinones - administration & dosage
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- Skin Neoplasms - drug therapy
- Triamcinolone Acetonide - therapeutic use
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- Visual Acuity - physiology
- Find related publications in this database (Keywords)
- Uveitis
- melanoma
- MEK inhibitor
- BRAF inhibitor
- ocular toxicity