Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Schwab, C; Paar, M; Fengler, VH; Lindner, E; Haas, A; Ivastinovic, D; Seidel, G; Weger, M; Wedrich, A; Oettl, K.
Vitreous albumin redox state in open-angle glaucoma patients and controls: a pilot study.
Int Ophthalmol. 2020; 40(4):999-1006
Doi: 10.1007/s10792-019-01268-5
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- Führende Autor*innen der Med Uni Graz
- Paar Margret
- Schwab Christoph
- Co-Autor*innen der Med Uni Graz
- Fengler Vera
- Haas Anton
- Ivastinovic Domagoj
- Lindner Ewald
- Öttl Karl
- Seidel Gerald
- Wedrich Andreas
- Weger Martin
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- Abstract:
- Numerous studies suggest that reactive oxygen species play a crucial role in the development of glaucoma. Since glaucoma patients exhibit posterior vitreous detachment earlier than controls, it has been suggested that reactive oxygen species-increased in glaucoma-also affect the vitreous. In the present study we evaluated the influence of open-angle glaucoma oxidative stress on the redox state of vitreous albumin. Albumin redox states of the vitreous and plasma were evaluated in 22 subjects-11 open-angle glaucoma patients and 11 controls-matched for age, gender, and vitreous state. According to the redox state of cysteine-34, albumin can be separated into: human mercaptalbumin (the thiol form), human nonmercaptalbumin1 (a reversible modification due to mild oxidation), and human nonmercaptalbumin2 (an irreversible modification due to severe oxidation). Albumin of both, the open-angle glaucoma group and the control group, was more oxidized in the vitreous compared to plasma. Furthermore, significantly higher human nonmercaptalbumin1 fractions were found in the vitreous of open-angle glaucoma patients compared to controls. No significant differences were found in the plasma albumin fractions between the groups. Our results support the hypothesis that oxidative stress plays a crucial role in open-angle glaucoma and that reactive oxygen species in glaucomatous eyes may also affect the vitreous.
- Find related publications in this database (Keywords)
- Glaucoma
- Open-angle glaucoma
- Vitreous
- Albumin
- Free radicals