Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Yu, Z; Wolf, P.
How It Works: The Immunology Underlying Phototherapy.
Dermatol Clin. 2020; 38(1):37-53
Doi: 10.1016/j.det.2019.08.004
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Wolf Peter
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- Abstract:
- Phototherapeutic modalities induce apoptosis of keratinocytes and immune cells, impact cytokine production, downregulate the IL-23/Th17 axis, and induce regulatory T cells. As in anti-IL-17 or anti-IL-23 antibody treatment, the dual action of phototherapy on skin and the immune system is likely responsible for sustained resolution of lesions in diseases such as psoriasis. In cutaneous T cell lymphoma, phototherapy may function by causing tumor cell apoptosis and eliminating the neoplastic and inflammatory infiltrate. Further research on phototherapeutic mechanisms will help advance, optimize, and refine dermatologic treatments and may open up novel avenues for treatment strategies in dermatology and beyond. Copyright © 2019 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Humans -
- Immunity, Cellular -
- Keratinocytes - immunology
- Keratinocytes - pathology
- Phototherapy - methods
- Psoriasis - immunology
- Psoriasis - pathology
- Psoriasis - therapy
- T-Lymphocytes, Regulatory - immunology
- Find related publications in this database (Keywords)
- Phototherapy
- UV radiation
- Apoptosis
- Immunosuppression
- Urocanic acid
- Platelet-activating factor
- IL-23TTH17 axis
- Regulatory T cells (Tregs center dot)