Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Paraíso, AF; Sousa, JN; Andrade, JMO; Mangabeira, ES; Lelis, DF; de Paula, AMB; Martins, AMEB; Lima, WJN; Guimarães, ALS; Melo, GA; Schwarz, M; Santos, SHS.
Oral gallic acid improves metabolic profile by modulating SIRT1 expression in obese mice brown adipose tissue: A molecular and bioinformatic approach.
Life Sci. 2019; 237(1):116914-116914
Doi: 10.1016/j.lfs.2019.116914
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Andrä Michaela
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- Abstract:
- The aim of the presente study was to examine the effects of oral gallic acid (GA) administration on the brown adipose tissue of obese mice fed with high-fat diet. New mechanisms and interactions pathways in thermogenesis were accessed through bioinformatics analyses. Swiss male mice were divided into four groups and fed during 60 days with: standard diet, standard diet combined with gallic acid, high-fat diet and high-fat diet combined with gallic acid. Body weight, food intake, and blood parameters (glucose tolerance test, total-cholesterol, high-density low-c, triglyceride and glucose levels) were evaluated. Brown and subcutaneous white adipose tissue histological analysis were performed. SIRT1 and PGC1-α mRNA expression in the brown adipose tissue were assessed. Our main findings showed that the gallic acid improved glucose tolerance and metabolic parameters. These results were accompanied by bioinformatics analyses that evidenced SIRT1 as main target in the thermogenesis process, confirmed as increased SIRT1 mRNA expression was evidenced in the brown adipose tissue. Together, the data suggest that the gallic acid effect in brown adipose tissue may improve body metabolism, glucose homeostasis and increase thermogenesis. Copyright © 2019 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipose Tissue, Brown - drug effects
- Adipose Tissue, Brown - metabolism
- Adipose Tissue, Brown - pathology
- Animals -
- Computational Biology - methods
- Diet, High-Fat - adverse effects
- Gallic Acid - pharmacology
- Gene Expression Regulation - drug effects
- Male -
- Metabolome - drug effects
- Mice -
- Mice, Obese -
- Obesity - drug therapy
- Obesity - etiology
- Obesity - metabolism
- Sirtuin 1 - genetics
- Sirtuin 1 - metabolism
- Thermogenesis - drug effects
- Find related publications in this database (Keywords)
- Gallic acid
- Sirtuins
- Obesity
- Thermogenesis
- Metabolism
- Bioinformatic