Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Smolle, E; Leithner, K; Olschewski, H.
Oncogene addiction and tumor mutational burden in non-small-cell lung cancer: Clinical significance and limitations.
Thorac Cancer. 2020; 11(2):205-215
Doi: 10.1111/1759-7714.13246
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- Führende Autor*innen der Med Uni Graz
- Taucher Elisabeth
- Co-Autor*innen der Med Uni Graz
- Leithner Katharina
- Olschewski Horst
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- Abstract:
- Lung cancer incidence has increased worldwide over the past decades, with non-small cell lung cancer (NSCLC) accounting for the vast majority (85%) of lung cancer specimens. It is estimated that lung cancer causes about 1.7 million global deaths per year worldwide. Multiple trials have been carried out, with the aim of finding new effective treatment options. Lately, special focus has been placed on immune checkpoint (PD1/PD-L1) inhibitors which impact the tumor immune microenvironment. Tumor mutational burden (TMB) has been found to predict response to immune checkpoint inhibitors. Conversely, recent studies have weakened the significance of TMB as a predictor of response to therapy and survival. In this review article, we discuss the significance of TMB, as well as possible limitations. Furthermore, we give a concise overview of mutations frequently found in NSCLC, and discuss the significance of oncogene addiction in lung cancer as an essential driver of tumorigenesis and tumor progression.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Biomarkers, Tumor - genetics
- Carcinoma, Non-Small-Cell Lung - genetics, pathology
- Disease Progression - administration & dosage
- Humans - administration & dosage
- Lung Neoplasms - genetics, pathology
- Mutation - administration & dosage
- Oncogene Addiction - genetics
- Tumor Microenvironment - administration & dosage
- Find related publications in this database (Keywords)
- Mutational burden
- non-small cell lung cancer
- oncogene addiction