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SHR Neuro Cancer Cardio Lipid Metab Microb
Schnedl, WJ; Schenk, M; Lackner, S; Enko, D; Mangge, H; Forster, F.
Diamine oxidase supplementation improves symptoms in patients with histamine intolerance
FOOD SCI BIOTECHNOL. 2019; 28(6): 1779-1784.
Doi: 10.1007/s10068-019-00627-3
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- Leading authors Med Uni Graz
- Schnedl Wolfgang
- Co-authors Med Uni Graz
- Enko Dietmar
- Lackner Sonja
- Mangge Harald
- Schenk Michael
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- Abstract:
- Histamine intolerance (HIT) is thought to be caused by a disproportionate amount of histamine in the body. The enzyme diamine oxidase (DAO) is considered for the gastrointestinal degradation of histamine. For this open-label interventional pilot study, we identified 28 patients with HIT. For 4 weeks, they were instructed to take DAO capsules before meals. Then, throughout a follow-up period, they were instructed not to take the DAO. We used a questionnaire that included 22 symptoms, which were divided into 4 categories, as well as a symptom severity score. All symptoms improved significantly during the oral supplementation of DAO. During the follow-up period, without DAO supplementation, the symptoms sum scores increased again. The symptom intensity score was reduced for all symptoms. We have demonstrated, a significant reduction of every HIT-related symptom and its intensity due to DAO oral supplements. The ClinicalTrials.gov identifier (NCT number) is NCT03298568. © The Author(s) 2019.
- Find related publications in this database (Keywords)
- Histamine
- Diamine oxidase
- Malabsorption
- Gastrointestinal
- Extra-intestinal