Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Trummer, C; Ratz, B; Pandis, M; Pilz, S; Theiler-Schwetz, V.
Adrenal crisis-strategies for therapy and prevention
AUST J CLIN ENDOCR M. 2019;
Doi: 10.1007/s41969-019-00082-9
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- Führende Autor*innen der Med Uni Graz
- Theiler-Schwetz Verena
- Trummer Christian
- Co-Autor*innen der Med Uni Graz
- Pandis Marlene
- Pilz Stefan
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- Abstract:
- Despite current hormone replacement schemes, chronic adrenal insufficiency is still associated with increased mortality. Reasons include the occurrence of adrenal crises, triggered by situations of acute cortisol deficiency mostly due to increased need, e.g. in cases of gastroenteritis, infections, and inadequate intake of medications. A pragmatic definition of adrenal crisis is an acute deterioration in health associated with absolute (systolic blood pressure <100mmHg) or relative hypotension (systolic blood pressure >= 20mmHg lower than usual), with features that resolve within 1 to 2h after parenteral glucocorticoid administration. Due to unspecific symptoms and the rare occurrence of an adrenal crisis, many patients are still inadequately treated. Regular patient education programs are warranted for patients with primary and secondary adrenal insufficiency for the prevention, detection, and correct management of adrenal crisis. Aims include teaching patients to carry out dose adaptations in situations with increased need and to handle their emergency kit correctly, i.e. to correctly perform subcutaneous hydrocortisone injections in the case of an impending adrenal crisis.
- Find related publications in this database (Keywords)
- Adrenal insufficiency
- Cortisol deficiency
- Hydrocortisone
- Emergency kit
- Hypotension