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SHR Neuro Cancer Cardio Lipid Metab Microb

Madreiter-Sokolowski, CT; Ramadani-Muja, J; Ziomek, G; Burgstaller, S; Bischof, H; Koshenov, Z; Gottschalk, B; Malli, R; Graier, WF.
Tracking intra- and inter-organelle signaling of mitochondria.
FEBS J. 2019; 286(22):4378-4401 Doi: 10.1111/febs.15103 [OPEN ACCESS]
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Leading authors Med Uni Graz: Madreiter-Sokolowski Corina
Co-authors Med Uni Graz: Bischof Helmut; Burgstaller Sandra; Gottschalk Benjamin; Graier Wolfgang; Koshenov Zhanat; Malli Roland; Ramadani-Muja Jeta; Ziomek Gabriela
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Abstract:: Mitochondria are as highly specialized organelles and masters of the cellular energy metabolism in a constant and dynamic interplay with their cellular environment, providing adenosine triphosphate, buffering Ca²⁺ and fundamentally contributing to various signaling pathways. Hence, such broad field of action within eukaryotic cells requires a high level of structural and functional adaptation. Therefore, mitochondria are constantly moving and undergoing fusion and fission processes, changing their shape and their interaction with other organelles. Moreover, mitochondrial activity gets fine-tuned by intra- and interorganelle H⁺ , K⁺ , Na⁺ , and Ca²⁺ signaling. In this review, we provide an up-to-date overview on mitochondrial strategies to adapt and respond to, as well as affect, their cellular environment. We also present cutting-edge technologies used to track and investigate subcellular signaling, essential to the understanding of various physiological and pathophysiological processes. © 2019 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
Find related publications in this database (Keywords): calcium; intracellular signaling; mitochondria; mitochondria-associated ER membranes; mitochondrial membrane potential; mitochondrial structure; potassium