Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kargl, S; Gitter, R; Pumberger, W.
Cholelithiasis in children with CHD: is it a problem?
Cardiol Young. 2017; 27(4): 630-633.
Doi: 10.1017/S1047951116000846
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Kargl Simon
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- Abstract:
- An association of heart disease and its treatment with biliary calculi is popularly accepted. We sought determine the prevalence and risk factors of paediatric gallstone disease in the presence of CHD and analyse the treatment options. We evaluated the role of open-heart surgery in the development of gallstones in patients with CHD. Patients and methods In a 10-year, retrospective, chart review (2005-2014), patients with CHD and cholelithiasis were identified and reviewed. In all, 19 of 4729 children with CHD had cholelithiasis (0.4%); eight patients underwent cardiac surgery before diagnosis of cholelithiasis (group 1), whereas 11 of them had not (group 2). The prevalence was 0.3% in group 1 and 0.5% in group 2. In nine asymptomatic patients, gallstones were found incidentally. Children with cholecystolithiasis (n=17) received ursodeoxycholic acid. A resolution of gallstones was found in four cases; two patients underwent biliary surgery, and the others (15/17) were successfully managed non-operatively. Despite an accumulation of risk factors, prevalence of gallstones is not as high as expected in children with CHD. Open-heart surgery with a heart-lung machine plays a minor role as an aetiological factor. In about half of the cases, cholelithiasis is an incidental finding and patients stay asymptomatic. Prophylactic administration of ursodeoxycholic acid is not indicated in children undergoing open-heart surgery for CHDs. Biliary surgery is reserved for patients with recurrent symptoms or cholestasis. In children with CHD, cholelithiasis is a minor and manageable co-morbid condition.
- Find related publications in this database (using NLM MeSH Indexing)
- Austria - epidemiology
- Cardiac Surgical Procedures - adverse effects
- Child -
- Child, Preschool -
- Comorbidity -
- Disease Management -
- Female -
- Gallstones - diagnostic imaging
- Gallstones - epidemiology
- Gallstones - therapy
- Heart Defects, Congenital - complications
- Heart Defects, Congenital - surgery
- Humans -
- Infant -
- Infant, Newborn -
- Male -
- Prevalence -
- Retrospective Studies -
- Risk Factors -
- Ultrasonography -
- Find related publications in this database (Keywords)
- CHD
- cholelithiasis
- children