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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Bernardelli de Mattos, I; Nischwitz, SP; Tuca, AC; Groeber-Becker, F; Funk, M; Birngruber, T; Mautner, SI; Kamolz, LP; Holzer, JCJ.
Delivery of antiseptic solutions by a bacterial cellulose wound dressing: Uptake, release and antibacterial efficacy of octenidine and povidone-iodine.
Burns. 2020; 46(4):918-927
Doi: 10.1016/j.burns.2019.10.006
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Geißler Judith Christine Julie
- Co-authors Med Uni Graz
- Birngruber Thomas
- Kamolz Lars-Peter
- Mautner Selma
- Nischwitz Sebastian
- Tuca Alexandru
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- Abstract:
- Bacterial nanocellulose (BNC) is considered a promising carrier for various substances and novel approaches using BNC in combination with antiseptics are well documented. However, the difference in the molecular weight of these molecules influences their uptake by and release from BNC. Analysing the diffusion of standard molecules with different weight, e.g. dextrans, offers the possibility to investigate the mobility of various molecules. We aimed to test the use of BNC regarding uptake and release of different standard molecules as well as two commercially available antiseptics for possible applications in future wound dressings. Diffusion profiles, uptake and release of three FITC-dextran molecules differing in weight as well as octenidine (Octenisept®) and povidone-iodine (Betaisodona®)-based antiseptics were tested with BNC-based wound dressings. Furthermore, the antiseptic efficacy of BNC in combination with antiseptics against Staphylococcus aureus was tested. Uptake and release capacity for FITC-dextran molecules showed a molecular weight-dependent mobility from BNC into an agarose gel. The loading capacity of BNC was also inversely proportional to the molecular weight of the antiseptics. The release test for octenidine showed a sustained and prolonged delivery into a solid matrix, whereas povidone-iodine was released faster. Both antiseptic solutions combined with BNC showed a good dose-dependent efficacy against S. aureus. Results obtained from the mobility of FITC-dextran molecules in the BNC matrix could open possible applications for the combination of BNC with other molecules for medical applications. Combination of both tested antiseptics with BNC showed to be an efficient approach to control bacterial infections. Copyright © 2019 Elsevier Ltd and ISBI. All rights reserved.
- Find related publications in this database (Keywords)
- Bacterial nanocellulose
- Antiseptic uptake
- Antiseptic release
- Octenidine
- Povidone-iodine
- Antimicrobial wound dressing