Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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Rosenkranz, S; Diller, GP; Dumitrescu, D; Ewert, R; Ghofrani, HA; Grünig, E; Halank, M; Held, M; Kaemmerer, H; Klose, H; Kovacs, G; Konstantinides, S; Lang, IM; Lange, TJ; Leuchte, H; Mayer, E; Olschewski, A; Olschewski, H; Olsson, KM; Opitz, C; Schermuly, RT; Seeger, W; Wilkens, H; Hoeper, MM.
[Hemodynamic Definition of Pulmonary Hypertension: Commentary on the Proposed Change by the 6th World Symposium on Pulmonary Hypertension].
Dtsch Med Wochenschr. 2019; 144(19):1367-1372
Doi: 10.1055/a-0918-3772
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- Co-Autor*innen der Med Uni Graz
- Kovacs Gabor
- Olschewski Andrea
- Olschewski Horst
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- Abstract:
- The ESC/ERS guidelines (published at the end of 2015) and other international recommendations defined pulmonary hypertension (PH) by an invasively measured mean pulmonary arterial pressure (mPAP) ≥ 25 mmHg at rest. At the 6th World Symposium on Pulmonary Hypertension in Nice a modification of this hemodynamic definition in the sense of lowering the threshold to > 20 mmHg was proposed. A pulmonary vascular resistance (PVR) ≥ 3 Wood units (WU) is additionally required for the diagnosis of pre-capillary PH. This modification must be critically reviewed with regard to the underlying rationale and possible consequences. Therefore, a detailed explanation is required. In particular, it must be made clear that this change currently has no influence on the evidence-based and approval-compliant prescription of drugs for the targeted therapy of pulmonary arterial hypertension (PAH). © Georg Thieme Verlag KG Stuttgart · New York.
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