Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Delgado, G; Kleber, ME; Krämer, BK; Morcos, M; Humpert, PM; Wiegand, K; Mauldin, A; Kusterer, K; Enghöfer, M; März, W; Segiet, T; Lammert, A.
Dietary Intervention with Oatmeal in Patients with uncontrolled Type 2 Diabetes Mellitus - A Crossover Study.
Exp Clin Endocrinol Diabetes. 2019; 127(9):623-629
Doi: 10.1055/a-0677-6068
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- Co-Autor*innen der Med Uni Graz
- März Winfried
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- Abstract:
- In a pilot study, we evaluated the efficacy of two days of oatmeal on insulin resistance and glucose metabolism and found a marked decrease of insulin requirements. The most important shortcoming of that study was that the interventions were not isocaloric (diabetes adapted diet: 1500 kcal/d vs. oatmeal 1100 kcal/d). To address these drawbacks we designed the OatMeal And Insulin Resistance (OMA-IR) study. The study was a randomized, open label crossover dietary intervention study with consecutive inclusion of 15 patients with uncontrolled type 2 diabetes. The intervention comprised two days of oatmeal on days 3 and 4 of a 5 days hospital stay. During the control period, patients received a diabetes mellitus adapted diet only. The primary endpoint was the daily insulin requirement and glycemic control. Upon oatmeal treatment, the required insulin dose could be significantly reduced on the third and fourth day as compared to the second day of inpatient stay (82.0±30.3 and 69.9±29.9IU versus 112±36.2IU;P<0.001). During control treatment, insulin requirement did not change. There were no significant differences in the changes of mean blood glucose or fasting glucose between both treatments. HbA1c was lower four weeks after the oatmeal intervention. In this crossover study, two days of oatmeal intervention allowed a highly significant reduction of required daily insulin doses while maintaining adequate metabolic control as compared to a diabetes adapted diet only. The beneficial effects of the intervention might last for several weeks as shown by the lower HbA1c four weeks after the intervention. © Georg Thieme Verlag KG Stuttgart · New York.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Blood Glucose - metabolism
- Cross-Over Studies -
- Diabetes Mellitus, Type 2 - blood
- Diabetes Mellitus, Type 2 - diet therapy
- Female -
- Glycated Hemoglobin A - metabolism
- Humans -
- Insulin - administration & dosage
- Male -
- Middle Aged -
- Pilot Projects -
- Find related publications in this database (Keywords)
- insulin dose
- fasting glucose
- glycemic control