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SHR Neuro Cancer Cardio Lipid Metab Microb

Weaver, NA; Zhao, L; Biesbroek, JM; Kuijf, HJ; Aben, HP; Bae, HJ; Caballero, MÁA; Chappell, FM; Chen, CPLH; Dichgans, M; Duering, M; Georgakis, MK; van der Giessen, RS; Gyanwali, B; Hamilton, OKL; Hilal, S; Vom Hofe, EM; de Kort, PLM; Koudstaal, PJ; Lam, BYK; Lim, JS; Makin, SDJ; Mok, VCT; Shi, L; Valdés Hernández, MC; Venketasubramanian, N; Wardlaw, JM; Wollenweber, FA; Wong, A; Xin, X; Meta VCI Map consortium; Biessels, GJ.
The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study.
Alzheimers Dement (Amst). 2019; 11:310-326 Doi: 10.1016/j.dadm.2019.02.007 [OPEN ACCESS]
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Study Group Members Med Uni Graz:: Pirpamer Lukas
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Abstract:: The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies. Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage. Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage. Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.
Find related publications in this database (Keywords): Cerebrovascular disease; Vascular cognitive impairment; Stroke; Small vessel disease; Consortium; Data harmonization; Support vector regression; Lesion-symptom mapping; Lesion location