Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mardanpour, P; Nayernia, K; Khodayari, S; Khodayari, H; Molcanyi, M; Hescheler, J.
Application of Stem Cell Technologies to Regenerate Injured Myocardium and Improve Cardiac Function.
Cell Physiol Biochem. 2019; 53(1): 101-120.
Doi: 10.33594/000000124
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- Führende Autor*innen der Med Uni Graz
- Molcanyi Marek
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- Abstract:
- In the recent decades, cardiovascular diseases emerged as the major leading cause of human mortality. However, current clinical approaches still do not encompass a thorough therapeutic solution for improving heart function of the patients who suffered an extensive myocardial injury. Based on this status quo, stem cells could become a novel option, as a natural source of the new myocardium lineage cells, being capable of paracrine factors secretion, protection or even regeneration of the damaged heart muscle. Efficient stem cell-based therapy of the heart should lead to repair or/and replacement of the degenerated tissue with functional myocardial and endothelial cells. Hereon, various types of pluripotent and multipotent stem cells have been already studied in the pre-clinical and clinical settings, demonstrating their cardiomyogenic and regenerative potential. In this context, as a type of male adult stem/ progenitors, spermatogonial stem cells feature a remarkable ability for a formation of cardiovascular lineages, based on our own observations. Presented data supports the presumption, that spermatogonial stem cells not only have a suitable capacity to generate functional heart cells but can also potentially improve the function of an injured myocardium. In this review article, we first describe the essential molecular and pathophysiological mechanisms involved in the heart tissue injury. Afterwards, based on our ongoing study, we review the impact of the stem cell technologies on the regeneration therapy in cardiovascular and myocardial diseases. Particular emphasis is being put on the usability of spermatogonial stem cells in cardiac therapy. © Copyright by the Author(s). Published by Cell Physiol Biochem Press.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult Germline Stem Cells - cytology
- Adult Germline Stem Cells - metabolism
- Adult Germline Stem Cells - transplantation
- Animals -
- Cell Differentiation -
- Heart - physiology
- Heart - physiopathology
- Heart Injuries - pathology
- Heart Injuries - physiopathology
- Heart Injuries - therapy
- Humans -
- Myocardium - cytology
- Myocardium - pathology
- Myocytes, Cardiac - cytology
- Myocytes, Cardiac - metabolism
- Myocytes, Cardiac - pathology
- Regeneration -
- Stem Cell Transplantation - methods
- Stem Cells - cytology
- Stem Cells - metabolism