Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pilz, S; Keppel, MH; Trummer, C; Theiler-Schwetz, V; Pandis, M; Borzan, V; Pittrof, M; Obermayer-Pietsch, B; Grübler, MR; Verheyen, N; Stepan, V; Meinitzer, A; Voelkl, J; März, W; Tomaschitz, A.
Diagnostic Accuracy of the Aldosterone-to-Active Renin Ratio for Detecting Primary Aldosteronism.
J Endocr Soc. 2019; 3(9):1748-1758
Doi: 10.1210/js.2019-00145
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Pilz Stefan
- Co-Autor*innen der Med Uni Graz
- Borzan Valentin
- Grübler Martin
- Keppel Martin Helmut
- März Winfried
- Meinitzer Andreas
- Obermayer-Pietsch Barbara
- Pandis Marlene
- Stepan Vinzenz
- Theiler-Schwetz Verena
- Tomaschitz Andreas
- Trummer Christian
- Verheyen Nicolas Dominik
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- CONTEXT: The aldosterone-to-active renin ratio (AARR) is the recommended screening test for primary aldosteronism (PA), but prospective study data on its sensitivity and specificity are sparse. OBJECTIVE: To investigate the diagnostic accuracy of the AARR for detecting PA. DESIGN: Prospective diagnostic accuracy study. SETTING: This study was conducted from February 2009 to August 2015 at the outpatient clinic of the Department of Endocrinology and Diabetology of the Medical University of Graz, Austria. PARTICIPANTS: Four hundred patients with arterial hypertension who were referred to a tertiary care center for screening for endocrine hypertension. INTERVENTION: Participants had a determination of the AARR (index test) and a second AARR determination followed by a saline infusion test (SIT) after 2 to 6 weeks. PA was diagnosed in individuals with any AARR ≥3.7 ng/dL/µU/mL [including a plasma aldosterone concentration (PAC) of ≥9 ng/dL] who had a PAC ≥10 ng/dL after the SIT. We did not substantially alter antihypertensive drug intake. MAIN OUTCOME MEASURES: Primary outcome was the receiver-operating characteristic (ROC) curve of the AARR in diagnosing PA. RESULTS: A total of 382 participants were eligible for analyses; PA was diagnosed in 18 (4.7%) patients. The area under the ROC curve of the AARR in detecting PA was 0.973 (95% CI, 0.956 to 0.990). Sensitivity and specificity for a positive AARR in diagnosing PA were 100% (95% CI, 81.5% to 100.0%) and 89.6% (95% CI, 86.0% to 92.5%), respectively. CONCLUSIONS: The AARR has good diagnostic accuracy for detecting PA.
- Find related publications in this database (Keywords)
- aldosterone
- diagnostic accuracy
- primary aldosteronism
- prospective
- renin