Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Delgado, GE; Zirlik, A; Gruber, R; Scheffold, T; Krämer, BK; März, W; Kleber, ME.
The association of high-normal international-normalized-ratio (INR) with mortality in patients referred for coronary angiography.
PLoS One. 2019; 14(8):e0221112-e0221112
Doi: 10.1371/journal.pone.0221112
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- Co-Autor*innen der Med Uni Graz
- März Winfried
- Zirlik Andreas
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- Abstract:
- The international-normalized-ratio (INR) is typically used to monitor patients on warfarin or related oral anticoagulant therapy. The aim of our study was to investigate the association of the INR with mortality in coronary artery disease (CAD) patients not on oral anticoagulant therapy. Between 1997 to 2000 the LUdwigshafen RIsk and Cardiovascular Health (LURIC) study enrolled 3316 patients of German ancestry that had been referred for coronary angiography. We excluded patients on coumarin therapy (n = 222) and patients with an INR more than 5 standard deviations (SD) away from the mean (n = 30). During a median follow-up of 9.9 years, 884 patients died, 547 patients from cardiovascular causes. After adjustment for cardiovascular risk factors the INR was associated with all-cause mortality in all patients and the CAD positive group with HRs (95% CI) of 1.14(1.07-1.21) and 1.16(1.09-1.23) per 1-SD increase, respectively. Adjustment for NT-proBNP rendered the association insignificant. In LURIC, the INR was positively associated with mortality in patients with prevalent CAD not on oral anticoagulant therapy as well as in patients without CAD. Adjustment for NT-proBNP abolished the association suggesting clinical or subclinical heart failure strongly contributing to increased INR and higher mortality.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Coronary Angiography -
- Coronary Artery Disease - blood
- Coronary Artery Disease - diagnostic imaging
- Coronary Artery Disease - drug therapy
- Coronary Artery Disease - mortality
- Female -
- Follow-Up Studies -
- Heart Failure - blood
- Heart Failure - diagnostic imaging
- Heart Failure - drug therapy
- Heart Failure - mortality
- Humans -
- International Normalized Ratio -
- Male -
- Middle Aged -
- Prospective Studies -
- Risk Factors -