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Selected Publication:
Hofer, A; Cerroni, L; Kerl, H; Wolf, P.
Narrowband (311-nm) UV-B therapy for small plaque parapsoriasis and early-stage mycosis fungoides.
Arch Dermatol. 1999; 135(11):1377-1380
Doi: 10.1001%2Farchderm.135.11.1377
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- Leading authors Med Uni Graz
- Hofer Angelika
- Wolf Peter
- Co-authors Med Uni Graz
- Cerroni Lorenzo
- Kerl Helmut
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- Abstract:
- BACKGROUND: Broadband UV-B phototherapy has been used for many years in the treatment of small plaque parapsoriasis (SPP) and early-stage mycosis fungoides (MF). Our purpose was to investigate the effect on these diseases of narrowband (311-nm) UV-B therapy, which was recently established for the treatment of psoriasis and found to be more effective than broadband UV-B therapy. OBSERVATIONS: Twenty patients (5 women, 15 men; age range, 39-85 years) with histologically confirmed SPP or early-stage MF were enrolled. Six patients had early-stage MF (patch stage), and 14 had SPP. Treatment with 311-nm UV-B was given 3 to 4 times a week for 5 to 10 weeks. In 19 patients, lesions completely cleared after a mean number of 20 treatments (range, 14-29 treatments) and a mean cumulative UV-B dose of 16.3J/cm2 (range, 7.4-36.4 J/cm2) within a mean time of 6 weeks (range, 5-10 weeks). Biopsy specimens taken immediately after the end of phototherapy showed only sparse inflammatory infiltrates but no signs of SPP or MF. Relapses at cutaneous sites occurred in all patients within a mean time of 6 months (range, 2-15 months). CONCLUSIONS: Narrowband UV-B therapy is an effective short-term treatment modality for clearing SPP and early-stage MF. However, the treatment response did not sustain long-term remission. Further studies are necessary to examine how the clinical response to and follow-up after narrowband UV-B therapy compares with that of established phototherapy modalities in these diseases.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Biopsy -
- Dose Fractionation -
- Female -
- Follow-Up Studies -
- Humans -
- Male -
- Middle Aged -
- Mycosis Fungoides - pathology
- Neoplasm Recurrence, Local - pathology
- Parapsoriasis - pathology
- Radiotherapy Dosage - pathology
- Recurrence - pathology
- Remission Induction - pathology
- Skin Neoplasms - pathology
- Treatment Outcome - pathology
- Ultraviolet Therapy - methods