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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Mayer-Pickel, K; Kolovetsiou-Kreiner, V; Stern, C; Münzker, J; Eberhard, K; Trajanoski, S; Lakovschek, IC; Ulrich, D; Csapo, B; Lang, U; Obermayer-Pietsch, B; Cervar-Zivkovic, M.
Effect of Low-Dose Aspirin on Soluble FMS-Like Tyrosine Kinase 1/Placental Growth Factor (sFlt-1/PlGF Ratio) in Pregnancies at High Risk for the Development of Preeclampsia.
J Clin Med. 2019; 8(9):
Doi: 10.3390/jcm8091429
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- Leading authors Med Uni Graz
- Mayer-Pickel Karoline Ilse
- Co-authors Med Uni Graz
- Cervar-Zivkovic Mila
- Csapo Bence Daniel
- Eberhard Katharina
- Gold ehem Ulrich Daniela
- Kolovetsiou-Kreiner Vassiliki
- Lakovschek Ioana-Claudia
- Lang Uwe
- Münzker Julia
- Obermayer-Pietsch Barbara
- Stern Christina
- Trajanoski Slave
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- Abstract:
- Soluble FMS-like Tyrosine Kinase 1 (sFlt-1) and placental growth factor (PlGF) have been reported to be highly predictive several weeks before the onset of preeclampsia. To investigate longitudinal changes of serum levels sFlt-1 and PlGF in pregnant women at high risk for the development of preeclampsia and to reveal an impact of aspirin on maternal serum concentrations of sFlt-1 and PlGF. This was a prospective longitudinal study in 394 women with various risk factors for the development of preeclampsia (chronic hypertension, antiphospholipid syndrome/APS or systemic lupus erythematosus/SLE, thrombophilia, women with a history of preeclampsia, pathologic first trimester screening for preeclampsia) and 68 healthy women. Serum levels of sFlt-1 and PlGF were measured prospectively at 4-week intervals (from gestational weeks 12 until postpartum). The sFlt-1/PlGF ratio was significantly higher in women with an adverse obstetric outcome compared to women with a normal pregnancy, starting between 20 and 24 weeks of gestation. There was no effect of aspirin on sFlt-1/PlGF ratio in women with chronic hypertension, APS/SLE, thrombophilia and controls. The use of aspirin showed a trend towards an improvement of the sFlt-1/PlGF ratio in women with preeclampsia in a previous pregnancy and a significant effect on the sFlt-1/PlGF ratio in women with a pathologic first trimester screening for preeclampsia. Our findings reveal an impact of aspirin on sFlt-1/PlGF ratio in women with a pathologic first trimester screening for preeclampsia, strongly supporting its prophylactic use.
- Find related publications in this database (Keywords)
- adverse pregnancy outcome
- aspirin
- first trimester screening for preeclampsia
- high-risk pregnancies
- preeclampsia
- sFlt1/PlGF ratio