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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Pernthaler, B; Kulnik, R; Gstettner, C; Salamon, S; Aigner, RM; Kvaternik, H.
A Prospective Head-to-Head Comparison of 18F-Fluciclovine With 68Ga-PSMA-11 in Biochemical Recurrence of Prostate Cancer in PET/CT.
Clin Nucl Med. 2019; 44(10): e566-e573-e566-e573.
Doi: 10.1097/RLU.0000000000002703
Web of Science
PubMed
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FullText_MUG
- Leading authors Med Uni Graz
- Pernthaler Birgit
- Co-authors Med Uni Graz
- Aigner Reingard
- Gstettner Christian
- Kulnik Roman
- Kvaternik Herbert
- Salamon Spela
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- Abstract:
- One of the major challenges for all imaging modalities is accurate detection of prostate cancer (PCa) recurrence. Beyond the established Ga-PSMA, a novel promising PET tracer in PCa imaging is F-fluciclovine. For evaluating the advantages and disadvantages and the comparability, we conducted a prospective head-to-head comparison on F-fluciclovine and Ga-PSMA-11 in patients with biochemical recurrence of PCa. 58 patients with biochemical recurrence of PCa after definitive primary therapy were included. Both scans were performed within a time window of mean 9.4 days. All scans were visually analyzed independently on a patient-, region- and lesion-based analysis. All the examinations were performed in the same medical department using identical scanners at any time. The overall detection rate for PCa recurrence was 79.3% in F-fluciclovine and 82.8% in Ga-PSMA-11 (P = 0.64). Local recurrence was detected in 37.9% on F-fluciclovine and in 27.6% on Ga-PSMA-11 (P = 0.03). Local pelvic lymph node recurrence was detected on F-fluciclovine versus Ga-PSMA-11 in 46.6% versus 50%, in extrapelvic lymph node metastases in 41.4% versus 51.7% and in bone metastases in 25.9% versus 36.2%. Lesion-based analysis showed identical findings in local pelvic lymph nodes in 39.7%, in extrapelvic lymph nodes in 22.4%, and in bone metastases in 13.8%. The advantage of F-fluciclovine is detecting curable localized disease in close anatomical relation to the urinary bladder, whereas Ga-PSMA-11 fails because of accumulation of activity in the urinary bladder. F-fluciclovine is almost equivalent to Ga-PSMA-11 in detecting distant metastases of PCa recurrence.
- Find related publications in this database (Keywords)
- F-18-fluciclovine
- F-18-FACBC
- Ga-68-PSMA-11
- prostate cancer
- biochemical recurrence
- PET
- CT