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SHR Neuro Cancer Cardio Lipid Metab Microb
Alcala, N; Leblay, N; Gabriel, AAG; Mangiante, L; Hervas, D; Giffon, T; Sertier, AS; Ferrari, A; Derks, J; Ghantous, A; Delhomme, TM; Chabrier, A; Cuenin, C; Abedi-Ardekani, B; Boland, A; Olaso, R; Meyer, V; Altmuller, J; Le Calvez-Kelm, F; Durand, G; Voegele, C; Boyault, S; Moonen, L; Lemaitre, N; Lorimier, P; Toffart, AC; Soltermann, A; Clement, JH; Saenger, J; Field, JK; Brevet, M; Blanc-Fournier, C; Galateau-Salle, F; Le Stang, N; Russell, PA; Wright, G; Sozzi, G; Pastorino, U; Lacomme, S; Vignaud, JM; Hofman, V; Hofman, P; Brustugun, OT; Lund-Iversen, M; Thomas de Montpreville, V; Muscarella, LA; Graziano, P; Popper, H; Stojsic, J; Deleuze, JF; Herceg, Z; Viari, A; Nuernberg, P; Pelosi, G; Dingemans, AMC; Milione, M; Roz, L; Brcic, L; Volante, M; Papotti, MG; Caux, C; Sandoval, J; Hernandez-Vargas, H; Brambilla, E; Speel, EJM; Girard, N; Lantuejoul, S; McKay, JD; Foll, M; Fernandez-Cuesta, L.
Integrative and comparative genomic analyses identify clinically relevant pulmonary carcinoid groups and unveil the supra-carcinoids.
Nat Commun. 2019; 10(1): 3407-3407.
Doi: 10.1038/s41467-019-11276-9
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- Co-authors Med Uni Graz
- Brcic Luka
- Popper Helmuth
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- Abstract:
- The worldwide incidence of pulmonary carcinoids is increasing, but little is known about their molecular characteristics. Through machine learning and multi-omics factor analysis, we compare and contrast the genomic profiles of 116 pulmonary carcinoids (including 35 atypical), 75 large-cell neuroendocrine carcinomas (LCNEC), and 66 small-cell lung cancers. Here we report that the integrative analyses on 257 lung neuroendocrine neoplasms stratify atypical carcinoids into two prognostic groups with a 10-year overall survival of 88% and 27%, respectively. We identify therapeutically relevant molecular groups of pulmonary carcinoids, suggesting DLL3 and the immune system as candidate therapeutic targets; we confirm the value of OTP expression levels for the prognosis and diagnosis of these diseases, and we unveil the group of supra-carcinoids. This group comprises samples with carcinoid-like morphology yet the molecular and clinical features of the deadly LCNEC, further supporting the previously proposed molecular link between the low- and high-grade lung neuroendocrine neoplasms.