Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Gewählte Publikation:

SHR Neuro Krebs Kardio Lipid Stoffw Microb

Gottschalk, B; Klec, C; Leitinger, G; Bernhart, E; Rost, R; Bischof, H; Madreiter-Sokolowski, CT; Radulović, S; Eroglu, E; Sattler, W; Waldeck-Weiermair, M; Malli, R; Graier, WF.
MICU1 controls cristae junction and spatially anchors mitochondrial Ca²⁺ uniporter complex.
Nat Commun. 2019; 10(1):3732-3732 Doi: 10.1038/s41467-019-11692-x [OPEN ACCESS]
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Führende Autor*innen der Med Uni Graz: Gottschalk Benjamin; Graier Wolfgang
Co-Autor*innen der Med Uni Graz: Bernhart Eva Maria; Bischof Helmut; EROGLU Emrah; Klec Christiane; Leitinger Gerd; Madreiter-Sokolowski Corina; Malli Roland; Radulovic Snjezana; Rost René; Sattler Wolfgang; Waldeck-Weiermair Markus
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Abstract:: Recently identified core proteins (MICU1, MCU, EMRE) forming the mitochondrial Ca²⁺ uniporter complex propelled investigations into its physiological workings. Here, we apply structured illumination microscopy to visualize and localize these proteins in living cells. Our data show that MICU1 localizes at the inner boundary membrane (IBM) due to electrostatic interaction of its polybasic domain. Moreover, this exclusive localization of MICU1 is important for the stability of cristae junctions (CJ), cytochrome c release and mitochondrial membrane potential. In contrast to MICU1, MCU and EMRE are homogeneously distributed at the inner mitochondrial membrane under resting conditions. However, upon Ca²⁺ elevation MCU and EMRE dynamically accumulate at the IBM in a MICU1-dependent manner. Eventually, our findings unveil an essential function of MICU1 in CJ stabilization and provide mechanistic insights of how sophistically MICU1 controls the MCU-Complex while maintaining the structural mitochondrial membrane framework.
Find related publications in this database (using NLM MeSH Indexing): Calcium - metabolism; Calcium Channels - metabolism; Calcium Signaling - physiology; Calcium-Binding Proteins - metabolism; Cation Transport Proteins - metabolism; Cell Line, Tumor -; HEK293 Cells -; HeLa Cells -; Humans -; MCF-7 Cells -; Membrane Potential, Mitochondrial - physiology; Mitochondrial Membrane Transport Proteins - metabolism; Mitochondrial Membranes - metabolism