Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lerchbaum, E; Trummer, C; Theiler-Schwetz, V; Kollmann, M; Wölfler, M; Pilz, S; Obermayer-Pietsch, B.
Effects of Vitamin D Supplementation on Body Composition and Metabolic Risk Factors in Men: A Randomized Controlled Trial.
Nutrients. 2019; 11(8):
Doi: 10.3390/nu11081894
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- Führende Autor*innen der Med Uni Graz
- Lerchbaum Elisabeth
- Co-Autor*innen der Med Uni Graz
- Kollmann Martina
- Obermayer-Pietsch Barbara
- Pilz Stefan
- Theiler-Schwetz Verena
- Trummer Christian
- Wölfler Monika Martina
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- Abstract:
- Vitamin D might play a role in metabolic processes and obesity. We therefore examined vitamin D effects on metabolic markers and obesity in a randomized controlled trial (RCT). This is a post-hoc analysis of the Graz Vitamin D&TT-RCT, a single-center, double-blind, randomized placebo-controlled trial. We included 200 healthy men with serum 25-hydroxyvitamin D (25(OH) D) levels <75 nmol/L. Subjects received 20,000 IU of vitamin D3/week (n = 100) or placebo (n = 100) for 12 weeks. Outcome measures were metabolic markers, anthropometric measures, and body composition assessed by Dual-energy X-ray absorptiometry. One-hundred and ninety-two men completed the study. We found a significant treatment effect on fasting glucose/fasting insulin ratio (-5.3 (-10.4 to -0.2), p = 0.040), whereas we observed no significant effect on the remaining outcome parameters. In subgroup analyses of men with baseline 25(OH)D levels <50 nmol/L (n = 80), we found a significant effect on waist circumference (1.6 (0.3 to 2.9) cm, p = 0.012), waist-to-hip ratio (0.019 (0.002 to 0.036), p = 0.031), total body fat (0.029 (0.004 to 0.055) %, p = 0.026), and android fat (1.18 (0.11 to 2.26) %, p = 0.010). In middle-aged healthy men, vitamin D treatment had a negative effect on insulin sensitivity. In vitamin D deficient men, vitamin D has an unfavorable effect on central obesity and body composition.
- Find related publications in this database (using NLM MeSH Indexing)
- Adiposity - drug effects
- Adolescent -
- Adult -
- Age Factors -
- Aged -
- Aged -
- Biomarkers - blood
- Blood Glucose - drug effects
- Blood Glucose - metabolism
- Cholecalciferol - adverse effects
- Dietary Supplements - adverse effects
- Double-Blind Method -
- Humans -
- Insulin - blood
- Insulin Resistance -
- Male -
- Middle Aged -
- Obesity, Abdominal - blood
- Obesity, Abdominal - chemically induced
- Obesity, Abdominal - physiopathology
- Risk Factors -
- Sex Factors -
- Treatment Outcome -
- Vitamin D - analogs & derivatives
- Vitamin D - blood
- Vitamin D Deficiency - blood
- Vitamin D Deficiency - drug therapy
- Vitamin D Deficiency - physiopathology
- Waist Circumference -
- Waist-Hip Ratio -
- Young Adult -
- Find related publications in this database (Keywords)
- vitamin D
- randomized controlled trial
- insulin sensitivity
- obesity
- body composition