Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Stojković, R; Fucic, A; Ivanković, D; Jukić, Z; Radulović, P; Grah, J; Kovačević, N; Barišić, L; Krušlin, B.
Age and sex differences in genome damage between prepubertal and adult mice after exposure to ionising radiation.
Arh Hig Rada Toksikol. 2016; 67(4):297-303
Doi: 10.1515/aiht-2016-67-2882
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- Co-Autor*innen der Med Uni Graz
- Grah Josip Joachim
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- Abstract:
- The mechanisms that lead to sex and age differences in biological responses to exposure to ionising radiation and related health risks have still not been investigated to a satisfactory extent. The significance of sex hormones in the aetiology of radiogenic cancer types requires a better understanding of the mechanisms involved, especially during organism development. The aim of this study was to show age and sex differences in genome damage between prepubertal and adult mice after single exposure to gamma radiation. Genome damage was measured 24 h, 48 h, and 72 h after exposure of 3-week and 12-week old BALB/CJ mice to 8 Gy of gamma radiation using an in vivo micronucleus assay. There was a significantly higher genome damage in prepubertal than in adult animals of both sexes for all sampling times. Irradiation caused a higher frequency of micronuclei in males of both age groups. Our study confirms sex differences in the susceptibility to effects of ionising radiation in mice and is the first to show that such a difference occurs already at prepubertal age.
- Find related publications in this database (using NLM MeSH Indexing)
- Age Factors -
- Animals -
- Cell Survival - radiation effects
- DNA Damage - radiation effects
- Dose-Response Relationship, Radiation -
- Female -
- Gamma Rays - adverse effects
- Male -
- Mice -
- Mice, Inbred BALB C -
- Radiation Injuries - etiology
- Sex Factors -
- Find related publications in this database (Keywords)
- gamma radiation
- micronucleus
- oestrogen
- radiosensitivity
- testosterone