Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Emran, AA; Marzese, DM; Menon, DR; Hammerlindl, H; Ahmed, F; Richtig, E; Duijf, P; Hoon, DS; Schaider, H.
Commonly integrated epigenetic modifications of differentially expressed genes lead to adaptive resistance in cancer.
EPIGENOMICS-UK. 2019; 11(7): 732-737.
Doi: 10.2217/epi-2018-0173
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Schaider Helmut
- Co-Autor*innen der Med Uni Graz
- Richtig Erika
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Aim: To investigate the integrated epigenetic regulation of acquired drug resistance in cancer. Materials & methods: Our gene expression data of five induced drug-tolerant cell models, one resistant cell line and one publicly available drug-resistant dataset were integrated to identify common differentially expressed genes and pathways. ChIP-seq and DNA methylation by HM450K beadchip were used to study the epigenetic profile of differential expressed genes. Results & conclusion: Integrated transcriptomic analysis identified a common 'viral mimicry' related gene signature in induced drug-tolerant cells and the resistant state. Analysis of the epigenetic regulation revealed a common set of down-regulated genes, which are marked and regulated by a concomitant loss of H3K4me3, gain of H3K9me3 and increment of regional DNA methylation levels associated with tumor suppressor genes and apoptotic signaling.
- Find related publications in this database (Keywords)
- adaptive resistance
- differentially expressed genes
- DNA methylation
- epigenetic remodeling
- IDTC
- induced drug-tolerant cell
- LINE-1
- repressive histone marks
- viral mimicry