Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Rawlings, SA; Heldt, S; Prattes, J; Eigl, S; Jenks, JD; Flick, H; Rabensteiner, J; Prüller, F; Wölfler, A; Neumeister, P; Strohmaier, H; Krause, R; Hoenigl, M.
Using Interleukin 6 and 8 in Blood and Bronchoalveolar Lavage Fluid to Predict Survival in Hematological Malignancy Patients With Suspected Pulmonary Mold Infection.
Front Immunol. 2019; 10(2):1798-1798
Doi: 10.3389/fimmu.2019.01798
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- Führende Autor*innen der Med Uni Graz
- Hönigl Martin
- Co-Autor*innen der Med Uni Graz
- Eigl Susanne
- Flick Holger
- Heldt Sven
- Krause Robert
- Neumeister Peter
- Prattes Jürgen
- Prüller Florian
- Rabensteiner Jasmin
- Strohmaier Heimo
- Wölfler Albert
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- Abstract:
- Background: Molds and other pathogens induce elevated levels of several cytokines, including interleukin (IL)-6 and IL-8. The objective of this study was to investigate the prognostic value of IL-6 and IL-8 as well as fungal biomarkers in blood and bronchoalveolar lavage fluid (BAL) for overall survival in patients with underlying hematological malignancies and suspected mold infection. Methods: This cohort study included 106 prospectively enrolled adult cases undergoing bronchoscopy. Blood samples were collected within 24 h of BAL sampling and, in a subset of 62 patients, serial blood samples were collected up until 4 days after bronchoscopy. IL-6, IL-8, and other cytokines as well as galactomannan (GM) and β-D-glucan (BDG) were assayed in blood and BAL fluid and associations with overall mortality were assessed at the end of the study using receiver operating characteristic (ROC) curve analysis. Results: Both blood IL-8 (AUC 0.731) and blood IL-6 (AUC 0.699) as well as BAL IL-6 (AUC 0.763) and BAL IL-8 (AUC 0.700) levels at the time of bronchoscopy were predictors of 30-day all-cause mortality. Increasing blood IL-6 levels between bronchoscopy and day four after bronchoscopy were significantly associated with higher 90-day mortality, with similar findings for increasing IL-8 levels. In ROC analysis the difference of blood IL-8 levels between 4 days after bronchoscopy and the day of bronchoscopy had an AUC of 0.829 (95%CI 0.71-0.95; p < 0.001) for predicting 90-day mortality. Conclusions: Elevated levels of IL-6 and IL-8 in blood or BAL fluid at the time of bronchoscopy, and rising levels in blood 4 days following bronchoscopy were predictive of mortality in these patients with underlying hematological malignancy who underwent bronchoscopy for suspected mold infection.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Biomarkers - metabolism
- Bronchoalveolar Lavage Fluid -
- Bronchoscopy - methods
- Female -
- Fungi - metabolism
- Hematologic Neoplasms - metabolism
- Humans -
- Interleukin-6 - metabolism
- Interleukin-8 - metabolism
- Male -
- Mannans - metabolism
- Middle Aged -
- Prospective Studies -
- ROC Curve -
- Respiratory Tract Infections - metabolism
- Find related publications in this database (Keywords)
- hematologic malignancy
- invasive mold infection
- interleukin-6
- interleukin-8
- prognosis