Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Durchschein, F; Moazedi-Fuerst, F; Kielhauser, S; Lackner, A; Wiedner, M; Koch, H; Justich, I; Eherer, A.
Helpful, albeit hazardous! Esophageal stem-cell injection in systemic sclerosis.
Ther Adv Musculoskelet Dis. 2019; 11:1759720X19863618-1759720X19863618
Doi: 10.1177/1759720X19863618
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Baumann-Durchschein Franziska
- Moazedi-Fürst Florentine
- Co-Autor*innen der Med Uni Graz
- Eherer Andreas
- Justich Ivo
- Kielhauser Sonja
- Koch Horst
- Lackner Angelika
- Wiedner Maria
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- Abstract:
- Over 90% of patients with systemic sclerosis suffer from gastroesophageal reflux. Esophageal motility disturbances are associated with a reduced life quality and may force interstitial lung disease progression. We wanted to determine whether we can improve gastroesophageal reflux in these patients by esophageal stem-cell injection. We performed a pilot study including eights patients with systemic sclerosis and symptomatic gastroesophageal reflux. Sampling of adipose tissue was performed by an experienced plastic surgeon under local anesthesia. The collected fat was injected into the submucosa of the distal esophagus, each time 1 ml in all four quadrants starting 2, 4 and 6 cm proximal to the Z line (ending up to a total volume of 12 ml). Before the intervention, 3, 6 and finally 12 months after the procedure, patients answered the Gastroesophageal Reflux Disease Health-Related Quality of Life Questionnaire (GERD HRQL) and a high-resolution manometry was performed to quantify changes in motility function. All patients showed an improvement in the GERD HRQL score after the stem-cell injection and a lower dosage of proton-pump inhibitors. The manometric findings showed no change throughout the time. A serious adverse event occurred, as one patient developed multiple cerebellar embolic infarcts. Because of the favorable effect in all patients, a safe route for esophageal fat injection needs to be developed.
- Find related publications in this database (Keywords)
- gastroesophageal reflux
- stems cell injection
- systemic sclerosis