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Madreiter-Sokolowski, CT; Malli, RM; Graier, WF.
Mitochondrial-Endoplasmic Reticulum Interplay: A Lifelong On-Off Relationship?
Contact (Thousand Oaks). 2019; 2: 2515256419861227-2515256419861227. Doi: 10.1177/2515256419861227 [OPEN ACCESS]
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Leading authors Med Uni Graz: Graier Wolfgang; Madreiter-Sokolowski Corina
Co-authors Med Uni Graz: Malli Roland
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Abstract:: This article comments recent publications that highlight an intriguing importance of specific settings in the interaction between the mitochondria and the endoplasmic reticulum to ensure cell-specific functions like the responsiveness to elevated glucose in pancreatic β-cells. Hence, alterations of the mitochondria-endoplasmic reticulum communications under various pathological conditions like aging or cancer often come with enhanced Ca²⁺ transfer that, in turn, yields stimulation of basal mitochondrial activity to meet the increasing adenosine triphosphate demand of the very cell. Such observations identify mitochondria-associated membranes as potential target for new therapeutic strategies against aging or cancer.