Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Tomin, T; Schittmayer, M; Honeder, S; Heininger, C; Birner-Gruenberger, R.
Irreversible oxidative post-translational modifications in heart disease.
Expert Rev Proteomics. 2019; 16(8):681-693
Doi: 10.1080/14789450.2019.1645602
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- Führende Autor*innen der Med Uni Graz
- Birner-Grünberger Ruth
- Schittmayer-Schantl Matthias
- Tomin Tamara
- Co-Autor*innen der Med Uni Graz
- Heininger Christoph
- Honeder Sophie
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- Abstract:
- Introduction: Development of specific biomarkers aiding early diagnosis of heart failure is an ongoing challenge. Biomarkers commonly used in clinical routine usually act as readouts of an already existing acute condition rather than disease initiation. Functional decline of cardiac muscle is greatly aggravated by increased oxidative stress and damage of proteins. Oxidative post-translational modifications occur already at early stages of tissue damage and are thus regarded as potential up-coming disease markers. Areas covered: Clinical practice regarding commonly used biomarkers for heart disease is briefly summarized. The types of oxidative post-translational modification in cardiac pathologies are discussed with a special focus on available quantitative techniques and characteristics of individual modifications with regard to their stability and analytical accessibility. As irreversible oxidative modifications trigger protein degradation pathways or cause protein aggregation, both influencing biomarker abundance, a chapter is dedicated to their regulation in the heart.
- Find related publications in this database (Keywords)
- Heart failure
- oxidative stress
- post-translational modifications
- protein degradation
- protein aggregation