Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zweiker, D; Lambert, T; Steinwender, C; Weber, T; Suppan, M; Brussee, H; Niederl, E; Koppelstaetter, C; Kerschbaum, J; Watschinger, B; Hohenstein-Scheibenecker, K; Reindl-Schwaighofer, R; Sturmberger, T; Kindslehner, C; Weiss, TW; Rohla, M; Gruener, P; Maister, P; Auer, J; Dechant, C; Sykora, J; Krismer, C; Glaser, S; Zirlik, A; Zweiker, R.
Blood pressure changes after renal denervation are more pronounced in women and nondiabetic patients: findings from the Austrian Transcatheter Renal Denervation Registry.
J Hypertens. 2019; 37(11):2290-2297
Doi: 10.1097/HJH.0000000000002190
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Zweiker David
- Co-Autor*innen der Med Uni Graz
- Brussee Helmut
- Niederl Ella
- Zirlik Andreas
- Zweiker Robert
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- Abstract:
- Three recently published sham-controlled studies proved the efficacy of renal denervation (RDN) in hypertensive patients. The study presented here analyzed a nationwide multicentre registry database to clarify which patient subgroups benefit most from radiofrequency RDN. This is a post hoc analysis from the multicentre Austrian Transcatheter Renal Denervation Registry hosted by the Austrian Society of Hypertension. We correlated change of SBP after RDN to sex and presence/absence of comorbidities. Univariable correlation and multiple linear regression analyses were performed. Two hundred and ninety-one patients (43% women, median age 64 years) undergoing RDN between April 2011 and September 2014 were included in this analysis. Mean baseline ambulatory 24 h BP (systolic/diastolic) was 150 ± 18/89 ± 14 mmHg and mean baseline office BP was 170 ± 16/94 ± 14 mmHg.After RDN, mean ambulatory 24 h BP reduction was 9 ± 19/6 ± 16 mmHg. The following features were associated with a good response to RDN: high baseline systolic ambulatory BP, high baseline diastolic office BP, female sex, absence of diabetes mellitus, and absence of peripheral artery disease. Multivariable analysis identified female sex and absence of diabetes mellitus as strongest predictors for ambulatory BP reduction, although those groups had the lowest baseline ambulatory BP. Ambulatory BP reductions after RDN were substantially more pronounced in female and in nondiabetic patients despite lower baseline BP. It is concluded that in terms of efficacy female patients and nondiabetic patients might benefit more from RDN.
- Find related publications in this database (Keywords)
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