Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Moiseev, IS; Tsvetkova, T; Aljurf, M; Alnounou, RM; Bogardt, J; Chalandon, Y; Drokov, MY; Dvirnyk, V; Faraci, M; Friis, LS; Giglio, F; Greinix, HT; Kornblit, BT; Koelper, C; Koenecke, C; Lewandowski, K; Niederwieser, D; Passweg, JR; Peczynski, C; Penack, O; Peric, Z; Piekarska, A; Ronchi, PE; Rovo, A; Rzepecki, P; Scuderi, F; Sigrist, D; Siitonen, SM; Stoelzel, F; Sulek, K; Tsakiris, DA; Wilkowojska, U; Duarte, RF; Ruutu, T; Basak, GW.
Clinical and morphological practices in the diagnosis of transplant-associated microangiopathy: a study on behalf of Transplant Complications Working Party of the EBMT.
BONE MARROW TRANSPL. 2019; 54(7): 1022-1028.
Doi: 10.1038/s41409-018-0374-3
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Greinix Hildegard
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- Abstract:
- Transplant-associated thrombotic microangiopathy (TA-TMA) is a life-threatening complication of allogeneic hematopoietic stem cell transplantation (HSCT). This study evaluated clinical and morphological practices of TA-TMA diagnosis in EBMT centers. Two questionnaires, one for transplant physician and one for morphologist, and also a set of electronic blood slides from 10 patients with TA-TMA and 10 control patients with various erythrocyte abnormalities, were implemented for evaluation. Seventeen EBMT centers participated in the study. Regarding criteria used for TA-TMA diagnosis, centers reported as follows: 41% of centers used the International Working Group (IWG) criteria, 41% used "overall TA-TMA" criteria and 18% used physician's decision. The threshold of schistocytes to establish TA-TMA diagnosis in the participating centers was significantly associated with morphological results of test cases evaluations (p = 0.002). The mean number of schistocytes reported from blood slide analyses were 4.3 ± 4.5% for TA-TMA cases (range 0-19.6%, coefficient of variation (CV) 0.7) and 1.3 ± 1.6% for control cases (range 0-8.3%, CV 0.8). Half of the centers reported schistocyte levels below 4% for 7/10 TA-TMA cases. The intracenter variability was low, indicating differences in the institutional practices of morphological evaluation. In conclusion, the survey identified the need for the standardization of TA-TMA morphological diagnosis.